This paper describes the development and characterization of a microphysiology platform
for drug safety and efficacy in liver models of disease that includes a human, 3D …

Although the process of drug development requires efficacy and toxicity testing in animals
prior to human testing, animal models have limited ability to accurately predict human …

Microphysiological systems (MPSs) are dynamic cell culture systems that provide micro-
environmental and external cues to support physiologically relevant, organ-specific …

The liver is a heterogeneous organ with many vital functions, including metabolism of
pharmaceutical drugs and is highly susceptible to injury from these substances. The etiology …

In vitro models of the liver using isolated primary hepatocytes have been used as screens for
measuring the metabolism, toxicity and efficacy of xenobiotics, for studying hepatocyte …

This review summarizes some of the recent developments and identifies critical challenges
associated with in vitro and in silico representations of the liver and assesses the …

Microphysiology systems (MPS), also called organs-on-chips and tissue chips, are
miniaturized functional units of organs constructed with multiple cell types under a variety of …

Liver plays a major role in drug metabolism and is one of the main sites of drug adverse
effects. Microphysiological systems (MPS), also known as organs‐on‐a‐chip, are a class of …

Drug-induced liver injury (DILI) is a leading cause of drug attrition. Significant and well-
documented differences between animals and humans in liver pathways now necessitate …

Recent research has shown that the maintenance of relevant liver functions ex vivo requires
models in which the cells exhibit an in vivo‐like phenotype, often achieved by reconstitution …