Human mesenchymal stem cell derived exosomes alleviate type 2 diabetes mellitus by reversing peripheral insulin resistance and relieving β-cell destruction

Y Sun, H Shi, S Yin, C Ji, X Zhang, B Zhang, P Wu… - ACS …, 2018 - ACS Publications
Exosomes are nanosized extracellular vesicles (EVs) that show great promise in tissue
regeneration and injury repair as mesenchymal stem cell (MSC). MSC has been shown to …

[HTML][HTML] Mesenchymal stem cell-derived exosomes exert ameliorative effects in type 2 diabetes by improving hepatic glucose and lipid metabolism via enhancing …

Q He, L Wang, R Zhao, F Yan, S Sha, C Cui… - Stem cell research & …, 2020 - Springer
Background Mesenchymal stem cell (MSC)-based therapy is currently considered to be an
effective treatment strategy for diabetes and hepatic disorders, such as liver cirrhosis and …

[HTML][HTML] Mesenchymal stem cell exosomes as a new strategy for the treatment of diabetes complications

J Xiong, H Hu, R Guo, H Wang, H Jiang - Frontiers in Endocrinology, 2021 - frontiersin.org
Diabetes mellitus (DM) is a metabolic disease, now prevalent worldwide, which is
characterized by a relative or absolute lack of insulin secretion leading to chronically …

Impaired bone regenerative effect of exosomes derived from bone marrow mesenchymal stem cells in type 1 diabetes

Y Zhu, Y Jia, Y Wang, J Xu, Y Chai - Stem Cells Translational …, 2019 - academic.oup.com
Stem cell-derived exosomes have exhibited promise for applications in tissue regeneration.
However, one major problem for stem cell-derived exosome therapies is identifying …

[HTML][HTML] Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway

M Yu, W Liu, J Li, J Lu, H Lu, W Jia, F Liu - Stem cell research & therapy, 2020 - Springer
Background Mesenchymal stem cell (MSC)-derived exosomes emerge as promising
candidates for treating delayed wound healing in diabetes due to the promotion of …

[HTML][HTML] Mesenchymal stromal cell-derived exosomes ameliorate peripheral neuropathy in a mouse model of diabetes

B Fan, C Li, A Szalad, L Wang, W Pan, R Zhang… - Diabetologia, 2020 - Springer
Aims/hypothesis Diabetic peripheral neuropathy (DPN) is one of the major complications of
diabetes, which contributes greatly to morbidity and mortality. There is currently no effective …

[HTML][HTML] Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Accelerate Diabetic Wound Healing via Ameliorating Oxidative Stress and Promoting …

C Yan, Y Xv, Z Lin, Y Endo, H Xue, Y Hu… - … in bioengineering and …, 2022 - frontiersin.org
Diabetic wounds remain a great challenge for clinicians due to the multiple bacterial
infections and oxidative damage. Exosomes, as an appealing nanodrug delivery system …

[HTML][HTML] Exosomes derived from human umbilical cord mesenchymal stem cells accelerate diabetic wound healing via promoting M2 macrophage polarization …

L Teng, M Maqsood, M Zhu, Y Zhou, M Kang… - International Journal of …, 2022 - mdpi.com
Some scholars have suggested that the clinical application of exosomes derived from
human umbilical cord mesenchymal stem cells (hucMSCs-exo) might represent a novel …

Potential of stem cell‐derived exosomes to regenerate β islets through Pdx‐1 dependent mechanism in a rat model of type 1 diabetes

E Mahdipour, Z Salmasi… - Journal of cellular …, 2019 - Wiley Online Library
Type 1 diabetes, has been recognized as an autoimmune disease. Like other
immunological conditions, regulation of immune response is a key strategy to control the …

Mesenchymal stem cell-derived exosomes carry MicroRNA-125a to protect against diabetic nephropathy by targeting histone deacetylase 1 and downregulating …

Y Hao, J Miao, W Liu, K Cai, X Huang… - … Syndrome and Obesity, 2021 - Taylor & Francis
Background Mesenchymal stem cell (MSC)-derived exosomes have seen great advances in
human disease control in a minimally invasive manner. This research aimed to explore the …