Therapeutic hypothermia was investigated repeatedly as a tool to improve the outcome of
severe traumatic brain injury (TBI), but previous clinical trials and meta-analyses found …

The benefits of therapeutic hypothermia (TH) in severe traumatic brain injury (sTBI) have
been long debated. In 2018, the POLAR study, a high-quality international trial, appeared to …

ContextThe benefits of therapeutic hypothermia as a treatment for traumatic brain injury (TBI)
remain unclear. ObjectiveTo explore the effects of depth, duration, and rate of rewarming …

Introduction Many single-center studies and meta-analyses demonstrate that therapeutic
hypothermia (TH), in which the body temperature is maintained at 32–35° C, exerts …

Background Traumatic brain injury (TBI) is a major public health problem recently, however,
no intervention showing convincing efficacy. Therapeutic hypothermia with a relatively long …

Objectives: To evaluate the effect of moderate hypothermia treatment (MHT) in severe
traumatic brain injury (sTBI) compared to normothermia management. Methods: PubMed …

Background: Traumatic brain injury (TBI) is a worldwide health concern associated with
significant morbidity and mortality. In the United States, severe TBI is managed according to …

Background The efficacy of therapeutic hypothermia in adult patients with traumatic brain
injury is not fully understood. The historical use of therapeutic hypothermia at extreme …

In this study, we conducted an updated meta-analysis of the effects of hypothermia therapy
on mortality, favorable neurologic outcome, and associated adverse effects in adults with …

Two major studies in the field of therapeutic hypothermia—the National Acute Brain Injury
Study: Hypothermia I and II—have shown the high safety levels of body cooling …