Ca2+/calmodulin-dependent protein kinase II inhibitors disrupt AKAP79-dependent PKC signaling to GluA1 AMPA receptors
IM Brooks, SJ Tavalin - Journal of Biological Chemistry, 2011 - ASBMB
GluA1 (formerly GluR1) AMPA receptor subunit phosphorylation at Ser-831 is an early
biochemical marker for long-term potentiation and learning. This site is a substrate for Ca …
biochemical marker for long-term potentiation and learning. This site is a substrate for Ca …
AKAP79 selectively enhances protein kinase C regulation of GluR1 at a Ca2+-calmodulin-dependent protein kinase II/protein kinase C site
SJ Tavalin - Journal of Biological Chemistry, 2008 - ASBMB
Enhancement of AMPA receptor activity in response to synaptic plasticity inducing stimuli
may arise, in part, through phosphorylation of the GluR1 AMPA receptor subunit at Ser-831 …
may arise, in part, through phosphorylation of the GluR1 AMPA receptor subunit at Ser-831 …
Preferential generation of Ca2+-permeable AMPA receptors by AKAP79-anchored protein kinase C proceeds via GluA1 subunit phosphorylation at Ser-831
KC Summers, AS Bogard, SJ Tavalin - Journal of Biological Chemistry, 2019 - ASBMB
AMPA-type glutamate receptors (AMPARs) mediate fast excitatory neurotransmission in the
mammalian central nervous system. Preferential AMPAR subunit assembly favors …
mammalian central nervous system. Preferential AMPAR subunit assembly favors …
Ca2+/calmodulin-dependent protein kinase II binds to and phosphorylates a specific SAP97 splice variant to disrupt association with AKAP79/150 and modulate α …
Ca 2+/calmodulin-dependent protein kinase II (CaMKII) promotes trafficking and activation of
the GluR1 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate …
the GluR1 subunit of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate …
Interaction with AKAP79 modifies the cellular pharmacology of PKC
A-kinase anchoring proteins (AKAPs) coordinate cell signaling events. AKAP79 brings
together different combinations of enzyme binding partners to customize the regulation of …
together different combinations of enzyme binding partners to customize the regulation of …
PKC phosphorylates GluA1-Ser831 to enhance AMPA receptor conductance
MA Jenkins, SF Traynelis - Channels, 2012 - Taylor & Francis
AMPA receptors mediate fast excitatory synaptic transmission in the brain, and are
dynamically regulated by phosphorylation of multiple residues within the C-terminal domain …
dynamically regulated by phosphorylation of multiple residues within the C-terminal domain …
AKAPs (A-kinase anchoring proteins) and molecules that compose their G-protein-coupled receptor signalling complexes
CC Malbon, J Tao, H Wang - Biochemical Journal, 2004 - portlandpress.com
Cell signalling mediated via GPCRs (G-protein-coupled receptors) is a major paradigm in
biology, involving the assembly of receptors, G-proteins, effectors and downstream elements …
biology, involving the assembly of receptors, G-proteins, effectors and downstream elements …
AKAP150-anchored calcineurin regulates synaptic plasticity by limiting synaptic incorporation of Ca2+-permeable AMPA receptors
JL Sanderson, JA Gorski, ES Gibson… - Journal of …, 2012 - Soc Neuroscience
AMPA receptors (AMPARs) are tetrameric ion channels assembled from GluA1–GluA4
subunits that mediate the majority of fast excitatory synaptic transmission in the brain. In the …
subunits that mediate the majority of fast excitatory synaptic transmission in the brain. In the …
Adenylyl cyclase anchoring by a kinase anchor protein AKAP5 (AKAP79/150) is important for postsynaptic β-adrenergic signaling
Recent evidence indicates that the A kinase anchor protein AKAP5 (AKAP79/150) interacts
not only with PKA but also with various adenylyl cyclase (AC) isoforms. However, the …
not only with PKA but also with various adenylyl cyclase (AC) isoforms. However, the …
Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79) signaling complex shares properties with long-term depression
SJ Tavalin, M Colledge, JW Hell… - Journal of …, 2002 - Soc Neuroscience
Second messengers regulate synaptic plasticity by influencing the balance between kinase
and phosphatase activity. One target of this balance is the phosphorylation state of the …
and phosphatase activity. One target of this balance is the phosphorylation state of the …