Thousands of previously unknown phages discovered in whole-community human gut metagenomes

S Benler, N Yutin, D Antipov, M Rayko, S Shmakov… - Microbiome, 2021 - Springer
Background Double-stranded DNA bacteriophages (dsDNA phages) play pivotal roles in
structuring human gut microbiomes; yet, the gut virome is far from being fully characterized …

[HTML][HTML] Massive expansion of human gut bacteriophage diversity

LF Camarillo-Guerrero, A Almeida, G Rangel-Pineros… - Cell, 2021 - cell.com
Bacteriophages drive evolutionary change in bacterial communities by creating gene flow
networks that fuel ecological adaptions. However, the extent of viral diversity and its …

A highly abundant bacteriophage discovered in the unknown sequences of human faecal metagenomes

BE Dutilh, N Cassman, K McNair, SE Sanchez… - Nature …, 2014 - nature.com
Metagenomics, or sequencing of the genetic material from a complete microbial community,
is a promising tool to discover novel microbes and viruses. Viral metagenomes typically …

Genome signature-based dissection of human gut metagenomes to extract subliminal viral sequences

LA Ogilvie, LD Bowler, J Caplin, C Dedi… - Nature …, 2013 - nature.com
Bacterial viruses (bacteriophages) have a key role in shaping the development and
functional outputs of host microbiomes. Although metagenomic approaches have greatly …

Classification and quantification of bacteriophage taxa in human gut metagenomes

AS Waller, T Yamada, DM Kristensen… - The ISME …, 2014 - academic.oup.com
Bacteriophages have key roles in microbial communities, to a large extent shaping the
taxonomic and functional composition of the microbiome, but data on the connections …

Probing the “dark matter” of the human gut phageome: Culture assisted metagenomics enables rapid discovery and host-linking for novel bacteriophages

CB Fitzgerald, AN Shkoporov, A Upadrasta… - Frontiers in cellular …, 2021 - frontiersin.org
Recent years have been marked by the growing interest towards virulent and temperate
bacteriophage populations inhabiting the human lower gastrointestinal tract–the gut …

Bacteroides thetaiotaomicron-infecting bacteriophage isolates inform sequence-based host range predictions

AJ Hryckowian, BD Merrill, NT Porter, W Van Treuren… - Cell Host & Microbe, 2020 - cell.com
Our emerging view of the gut microbiome largely focuses on bacteria, while less is known
about other microbial components, such as bacteriophages (phages). Though phages are …

Metagenomic compendium of 189,680 DNA viruses from the human gut microbiome

S Nayfach, D Páez-Espino, L Call, SJ Low… - Nature …, 2021 - nature.com
Bacteriophages have important roles in the ecology of the human gut microbiome but are
under-represented in reference databases. To address this problem, we assembled the …

Diversity, evolution, and classification of virophages uncovered through global metagenomics

D Paez-Espino, J Zhou, S Roux, S Nayfach… - Microbiome, 2019 - Springer
Background Virophages are small viruses with double-stranded DNA genomes that
replicate along with giant viruses and co-infect eukaryotic cells. Due to the paucity of …

Shining light on human gut bacteriophages

E Guerin, C Hill - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
The human gut is a complex environment that contains a multitude of microorganisms that
are collectively termed the microbiome. Multiple factors have a role to play in driving the …