Simple Summary This review discusses new findings for the roles of TNFR1 and TNFR2 in
the development of aggressive lung squamous cell carcinoma and lung adenocarcinoma by …

Tumor necrosis factor receptor 1 (TNFR1), encoded by TNFRSF1A, is a critical transducer of
inflammatory pathways, but its physiological role in human cancer is not completely …

Background Tumor necrosis factor receptor 2 (TNFR2) promotes tumor cell proliferation,
activates immunosuppressive cells, and supports immune escape. However, its role in non …

Tumor necrosis factor receptor 2 (TNFR2), a membrane-bound tumor necrosis factor
receptor expressed by regulatory T cells (Tregs), participates in Treg proliferation. Although …

Tumor necrosis factor (TNF) is widely accepted as a tumor-suppressive cytokine via its
ubiquitous receptor TNF receptor 1 (TNFR1). The other receptor, TNFR2, is not only …

PD-L1 is abnormally regulated in many cancers and is critical for immune escape. Fully
understanding the regulation of PD-L1 expression is vital for improving the clinical efficacy of …

Tumour necrosis factor (TNF) receptor type II (TNFR2) is expressed in various tumour cells
and some immune cells, such as regulatory T cells and myeloid-derived suppressing cells …

Metastasis is a multi-step process that ultimately depends on the ability of disseminating
cancer cells to establish favorable communications with their microenvironment. The tumor …

The appreciation that cancer growth is promoted by a dynamic tumor microenvironment
(TME) has spawned novel approaches to cancer treatment. New therapies include agents …

The mechanisms by which chronic inflammatory lung diseases, particularly chronic
obstructive pulmonary disease, confer enhanced risk for lung cancer are not well-defined …