We have recently shown that combining the structural elements of 2′ O-methoxyethyl
(MOE) and locked nucleic acid (LNA) nucleosides yielded a series of nucleoside …

Antisense drug discovery technology is a powerful method to modulate gene expression in
animals and represents a novel therapeutic platform. 1 We have previously demonstrated …

Conspectus Efforts to chemically modify nucleic acids got underway merely a decade after
the discovery of the DNA double helix and initially targeted nucleosides and nucleotides …

To develop antisense oligonucleotides, novel nucleosides, 2′-O, 4′-C-ethylene
nucleosides and their corresponding phosphoramidites, were synthesized as building …

Chemically modified nucleic acids are currently being evaluated as potential antisense
compounds for therapeutic applications. 2 '-O-Ethylene glycol substituted …

Novel 5 '-O-DMT-and MMT-protected 3 '-C-methylene-modified thymidine, 5-methyluridine,
and 5-methylcytidine H-phosphonates 1− 7 with O-methyl, fluoro, hydrogen, and O-(2 …

Oligonucleotides that target mRNA have great promise as therapeutic agents for life-
threatening conditions but suffer from poor bioavailability, hence high cost. As currently …

“Uniformly” modified phosphodiester or phosphorothioate oligonucleotides incorporating 2'-
deoxy-2'-fluoroadenosine,-guanosine,-uridine, and-cytidine, reported herein for the first time …

The synthesis, biophysical, structural, and biological properties of both isomers of 3′-fluoro
hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides are reported …

Synthesis of the phosphate-methylated DNA dinucleotidesd (CpG)(4), d (GpC)(5), d
(ApC)(6), d (ApT)(7), d (ApA)(8), and d (CpC)(9) is described. The 9 …