The p53 tumor suppressor plays a central role in dictating cell survival and death as a
cellular sensor for a myriad of stresses including DNA damage, oxidative and nutritional …

The p53 tumor suppressor network plays a fundamental surveillance role in both
homeostatic and adaptive cell biology. p53 is one of the most important barriers against …

p53 has been referred to as the 'guardian of the genome'because of its role in protecting the
cell from DNA damage. p53 performs its duties by regulating cell-cycle progression and …

Mitochondria are essential organelles within the cell where most of the energy production
occurs by the oxidative phosphorylation system (OXPHOS). Critical components of the …

Alzheimer's disease (AD) exhibits extensive oxidative stress throughout the body, being
detected peripherally as well as associated with the vulnerable regions of the brain affected …

Mitochondria are organelles responsible for vital cell functions. p53 is a transcription factor
that regulates the DNA stability and cell growth normality. Recent studies revealed that p53 …

Mitochondria are cytoplasmic organelles responsible for life and death. Extensive evidence
from animal models, postmortem brain studies of and clinical studies of aging and …

Mitochondria are key cytoplasmic organelles, responsible for generating cellular energy,
regulating intracellular calcium levels, altering the reduction-oxidation potential of cells, and …

In the past decade, the genetic causes underlying familial forms of many neurodegenerative
disorders, such as Huntington's disease, Parkinson's disease, Alzheimer's disease …

There is mounting evidence for mitochondrial involvement in neurodegenerative diseases
including Alzheimer's and Parkinson's disease and amyotrophic lateral sclerosis …