Aucubin enhances the antitumor activity of cisplatin through the inhibition of PD-L1 expression in hepatocellular carcinoma

ZX Gao, ZS Zhang, J Qin, MZ Zhang, JL Cao, YY Li… - Phytomedicine, 2023 - Elsevier
Background Hepatocellular carcinoma (HCC) is a leading cause of cancer-associated
mortality in the world. However, the anticancer effects of aucubin against HCC have yet to be …

Huaier improves the efficacy of anti-PD-L1 Ab in the treatment of hepatocellular carcinoma by regulating tumor immune microenvironment

H Li, J You, Y Wei, L Zheng, J Yang, J Xu, Y Li, Z Li… - Phytomedicine, 2024 - Elsevier
Background Combination therapy is an effective method for augmenting the efficacy of
immune checkpoint inhibitors (ICIs). Huaier is a commonly used Chinese patent medicine …

H19-Wnt/β-catenin regulatory axis mediates the suppressive effects of apigenin on tumor growth in hepatocellular carcinoma

F Pan, YB Zheng, CJ Shi, F Zhang, J Zhang… - European Journal of …, 2021 - Elsevier
Hepatocellular Carcinoma (HCC) is one of the leading causes of cancer-related deaths in
the world. However, the effective pharmacological approaches remain scanty in clinical …

Apigenin, a flavonoid constituent derived from P. villosa, inhibits hepatocellular carcinoma cell growth by CyclinD1/CDK4 regulation via p38 MAPK-p21 signaling

Y Li, X Cheng, C Chen, W Huijuan, H Zhao… - … -Research and Practice, 2020 - Elsevier
Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality worldwide. Apigenin
was widely used in HCC treatment; however, the detailed mechanisms have not been …

[HTML][HTML] Avicularin ameliorates human hepatocellular carcinoma via the regulation of NF‑κB/COX‑2/PPAR‑γ activities

Z Wang, F Li, Y Quan, J Shen - Molecular Medicine …, 2019 - spandidos-publications.com
Hepatocellular carcinoma (HCC) has become a global public health problem. Therefore, the
development of novel and effective therapeutic agents for the treatment of HCC is …

Aucubin exerts anticancer activity in breast cancer and regulates intestinal microbiota

M Shao, Z Kuang, W Wang, S Li, G Li… - Evidence‐Based …, 2022 - Wiley Online Library
Aucubin, a natural compound isolated from herbal medicine, has been reported to possess
multiple beneficial properties. In this study, we aimed to verify the anticancer effect of …

Curcumol inhibits the expression of programmed cell death-ligand 1 through crosstalk between hypoxia-inducible factor-1α and STAT3 (T705) signaling pathways in …

HX Zuo, Y Jin, Z Wang, MY Li, ZH Zhang… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance Curcuma wenyujin is a Chinese traditional herbal
medicine that is commonly used as an anti-oxidant, anti-proliferative, and anti-tumorigenic …

[HTML][HTML] Identification of WT1 as determinant of heptatocellular carcinoma and its inhibition by Chinese herbal medicine Salvia chinensis Benth and its active …

N Wang, HY Tan, YT Chan, W Guo, S Li, Y Feng - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract Candidates from Chinese herbal Medicine might be preferable in drug discovery as
the abundant experiences of traditional use usually hint the clinical efficacy. In this study, we …

Polygonum cuspidatum Extract Induces Anoikis in Hepatocarcinoma Cells Associated with Generation of Reactive Oxygen Species and Downregulation of Focal …

B Hu, HM An, KP Shen, HY Song… - … and Alternative Medicine, 2012 - Wiley Online Library
Anoikis has been recognized as a potential target for anticancer therapy. Polygonum
cuspidatum (Huzhang) is a frequently used Chinese herb in hepatocarcinoma. In present …

[HTML][HTML] β-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1

X Li, Z Lin, B Zhang, L Guo, S Liu, H Li, J Zhang… - Scientific reports, 2016 - nature.com
Abstract β-elemene, a Curcuma wenyujin plant extract, has been used widely as a tumor
adjuvant therapeutic agent. However, how to obtain optimum therapeutic effects by …