Mitochondrial toxicity can result from antiviral nucleotide analog therapy used to control
human immunodeficiency virus type 1 infection. We evaluated the ability of such analogs to …

To examine the role of the mitochondrial polymerase (Pol γ) in clinically observed toxicity of
nucleoside analogs used to treat AIDS, we examined the kinetics of incorporation catalyzed …

ABSTRACT Emtricitabine [(−) FTC;(−)-β-l-2′-3′-dideoxy-5-fluoro-3′-thiacytidine] is an
oxathiolane nucleoside analog recently approved by the Food and Drug Administration for …

Several of the nucleoside analogs used in the treatment of AIDS exhibit a delayed clinical
toxicity limiting their usefulness. The toxicity of nucleoside analogs may be related to their …

Incorporation of nucleoside analogues by the mitochondrial DNA polymerase has been
implicated as the primary cause underlying many of the toxic side effects of these drugs in …

Saccharomyces cerevisiae mtDNA polymerase, isolated as a single 135-kDa recombinant
polypeptide, showed high processivity and a capacity to use poly (dA)• oligo (dT), poly (rA)• …

Although antiviral nucleoside analog therapy successfully delays progression of HIV
infection to AIDS, these drugs cause unwelcome side-effects by inducing mitochondrial …

Inhibition constants were determined for 16 nucleoside analog triphosphates against human
DNA polymerases alpha, beta, gamma, and epsilon, and 7 nucleoside analogs were …

Deoxynucleoside analogs, AZT and/or ddN, are the therapeutic agents currently utilized to
inhibit the human immunodeficiency virus (HIV) reverse transcriptase. The effects of their …

This study used DNA primer extension and sequencing gel analyses to evaluate the
molecular action of 2', 3'-didehydro-2', 3'-dideoxythymidine triphosphate (D4TTP), in …