Clathrin-mediated endocytosis (CME) requires energy input from actin polymerization in
mechanically challenging conditions. The roles of actin in CME are poorly understood due to …

Actin assembly facilitates vesicle formation in several trafficking pathways, including clathrin-
mediated endocytosis (CME). Interestingly, actin does not assemble at all CME sites in …

Background The dynamic actin cytoskeleton plays an important role in clathrin-mediated
endocytosis (CME). However, its exact functions remain uncertain as a result of a lack of …

Clathrin-mediated endocytosis in mammalian cells is critical for a variety of cellular
processes including nutrient uptake and cell surface receptor down-regulation. Despite the …

Clathrin-mediated endocytosis (CME) robustness under elevated membrane tension is
maintained by actin assembly–mediated force generation. However, whether more actin …

Clathrin-mediated endocytosis involves the sequential assembly of more than 60 proteins at
the plasma membrane. An important fraction of these proteins regulates the assembly of an …

Force generation by actin assembly shapes cellular membranes. An experimentally
constrained multiscale model shows that a minimal branched actin network is sufficient to …

Cell Biology: Actin Keeps Endocytosis on a Short Leash: Current Biology Skip to Main Content
Advertisement Current Biology This journal offers authors two options (open access or …

Actin dynamics generate forces to deform the membrane and overcome the cell's high turgor
pressure during clathrin-mediated endocytosis (CME) in yeast, but precise molecular details …

Actin polymerization often occurs at the plasma membrane to drive the protrusion of
lamellipodia and filopodia at the leading edge of migrating cells. A role for actin …