Differentiation and quantification of inflammation, demyelination and axon injury or loss in multiple sclerosis
Axon injury/loss, demyelination and inflammation are the primary pathologies in multiple
sclerosis lesions. Despite the prevailing notion that axon/neuron loss is the substrate of …
sclerosis lesions. Despite the prevailing notion that axon/neuron loss is the substrate of …
Non-invasive quantification of inflammation, axonal and myelin injury in multiple sclerosis
The aim of this study was to determine the feasibility of diffusion basis spectrum imaging in
multiple sclerosis at 7 T and to investigate the pathological substrates of tissue damage in …
multiple sclerosis at 7 T and to investigate the pathological substrates of tissue damage in …
The radial diffusivity and magnetization transfer pool size ratio are sensitive markers for demyelination in a rat model of type III multiple sclerosis (MS) lesions
Determining biophysical sensitivity and specificity of quantitative magnetic resonance
imaging is essential to develop effective imaging metrics of neurodegeneration. Among …
imaging is essential to develop effective imaging metrics of neurodegeneration. Among …
Diffusion basis spectrum imaging detects and distinguishes coexisting subclinical inflammation, demyelination and axonal injury in experimental autoimmune …
Clinicopathological paradox has hampered significantly the effective assessment of the
efficacy of therapeutic intervention for multiple sclerosis. Neuroimaging biomarkers of tissue …
efficacy of therapeutic intervention for multiple sclerosis. Neuroimaging biomarkers of tissue …
Quantification of increased cellularity during inflammatory demyelination
Multiple sclerosis is characterized by inflammatory demyelination and irreversible axonal
injury leading to permanent neurological disabilities. Diffusion tensor imaging demonstrates …
injury leading to permanent neurological disabilities. Diffusion tensor imaging demonstrates …
Detecting white matter alterations in multiple sclerosis using advanced diffusion magnetic resonance imaging
Multiple sclerosis is a neurodegenerative and inflammatory disease, a hallmark of which is
demyelinating lesions in the white matter. We hypothesized that alterations in white matter …
demyelinating lesions in the white matter. We hypothesized that alterations in white matter …
Myelin and axon pathology in multiple sclerosis assessed by myelin water and multi-shell diffusion imaging
Damage to the myelin sheath and the neuroaxonal unit is a cardinal feature of multiple
sclerosis; however, a detailed characterization of the interaction between myelin and axon …
sclerosis; however, a detailed characterization of the interaction between myelin and axon …
Characterization of normal-appearing white matter in multiple sclerosis using quantitative susceptibility mapping in conjunction with diffusion tensor imaging
Purpose Quantitative susceptibility mapping (QSM) is influenced by iron as well as myelin,
which makes interpretation of pathologic changes challenging. Concurrent acquisition of MR …
which makes interpretation of pathologic changes challenging. Concurrent acquisition of MR …
Radial diffusivity predicts demyelination in ex vivo multiple sclerosis spinal cords
EC Klawiter, RE Schmidt, K Trinkaus, HF Liang… - Neuroimage, 2011 - Elsevier
OBJECTIVE: Correlation of diffusion tensor imaging (DTI) with histochemical staining for
demyelination and axonal damage in multiple sclerosis (MS) ex vivo human cervical spinal …
demyelination and axonal damage in multiple sclerosis (MS) ex vivo human cervical spinal …
Advanced multicompartment diffusion MRI models and their application in multiple sclerosis
Conventional MR imaging techniques are sensitive to pathologic changes of the brain and
spinal cord seen in MS, but they lack specificity for underlying axonal and myelin integrity …
spinal cord seen in MS, but they lack specificity for underlying axonal and myelin integrity …