Osteogenesis imperfecta (OI) is a genetic disorder characterized by bone fragility, low bone
mass, fractures, and extraskeletal manifestations. Since OI is commonly caused by single …

Osteogenesis imperfecta (OI) is a genetic disease characterized by bone fragility and
repeated fractures. The bone fragility associated with OI is caused by a defect in collagen …

To develop a disease model for the human 'brittle bone'disease, osteogenesis imperfecta,
we have used gene editing to produce a facsimile of the patient heterozygous COL1A1 …

To develop a disease model for the human 'brittle bone'disease, osteogenesis imperfecta,
we used a simultaneous reprogramming and CRISPR-Cas9 genome editing method to …

Mesenchymal stem cells (MSCs) are adult cells with the capacity to differentiate into multiple
cell types, including bone, fat, cartilage, and muscle cells. In order to effectively utilize …

To develop an in vitro disease model of a human chondrodysplasia, we used CRISPR/Cas9
gene editing to generate a heterozygous COL2A1 exon 50 c. 3508 GGT> TCA (p. G1170S) …

Osteogenesis imperfecta (OI) is caused by dominant mutations in the type I collagen genes.
In principle, the skeletal abnormalities of OI could be treated by transplantation of patient …

Objective To investigate the efficacy of CRISPR-Cas9 mediated editing in human
chondrocytes, and to develop a genome editing approach relevant to cell-based repair …

Targeting Gene Therapy for Osteogenesis Imperfecta Page 1 The new england journal of
medicine n engl j med 350;22 www.nejm.org may 27, 2004 2302 clinical implications of basic …

Osteoarthritis (OA) is an incapacitating and one of the most common physically degenerative
conditions with an assorted etiology and a highly complicated molecular mechanism that to …