We review the role of cadherins and cadherin-related proteins in human cancer. Cellular
and animal models for human cancer are also dealt with whenever appropriate. E-cadherin …

Abstract Loss of cadherin 1 (CDH1; also known as epithelial cadherin (E-cadherin)) is used
for the diagnosis and prognosis of epithelial cancers. However, it should not be ignored that …

Cadherins play an important role in tissue homeostasis, as they are responsible for cell-cell
adhesion during embryogenesis, tissue morphogenesis, differentiation and carcinogenesis …

Molecular activities, regulating a balanced tissue organisation, are frequently disturbed
during cancer progression. These include protein ectodomain shedding, a post-translational …

We review the evidence suggesting the involvement of Cadherin 13 (CDH13, T‐cadherin, H‐
cadherin) in various cancers. CDH13 is an atypical member of the cadherin family, devoid of …

Cadherin family includes lists of transmembrane glycoproteins which mediate calcium-
dependent cell-cell adhesion. Cadherin-mediated adhesion regulates cell growth and …

In the context of cancer, E-cadherin has traditionally been categorized as a tumor
suppressor, given its essential role in the formation of proper intercellular junctions, and its …

Morphogenesis is the process by which cells become organized into distinctive structures
and histological patterns in the tissues and organs of the body. Cellular morphogenetic …

Proper embryonic development is guaranteed under conditions of regulated cell–cell and
cell–matrix adhesion. The cells of an embryo have to be able to distinguish their neighbours …

P-cadherin is a classical cell-to-cell adhesion molecule with a homeostatic function in
several normal tissues. However, its behaviour in the malignant setting is notably dependent …