Abstract CD4+ CD25+ regulatory T cells (Tregs) are a class of CD4+ T cells with
immunosuppressive functions that play a critical role in maintaining immune homeostasis …

Regulatory T cells (Treg) are an important immune cell population, playing a crucial role in
regulating immune tolerance and preventing autoimmune diseases. These cells consist of …

In recent years, the understanding of regulatory T cell (Treg cell) biology has expanded
considerably. Key observations have challenged the traditional definition of Treg cells and …

Abstract Foxp3+ regulatory T (Treg) cells are considered a sub-lineage of CD4+ T cells that
are protective against autoimmunity due to their essential roles in maintaining immune …

Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …

Regulatory T cells (Tregs) are central to the maintenance of self-tolerance and tissue
homeostasis. Markers commonly used to define human Tregs in the research setting include …

Regulatory T cells (Tregs) play a key role in the peripheral self‐tolerance and preventing
autoimmunity. While classical CD4+ Foxp3+ Tregs are well established, their CD8+ …

Regulatory T (TReg) cells are crucial for the prevention of fatal autoimmunity in mice and
humans. Forkhead box P3 (FOXP3)+ TReg cells are produced in the thymus and are also …

Regulatory T cells (Treg) play a dominant role in suppression of autoimmune pathology, as
rescue of Treg number and/or function in model systems can both prevent and reverse …

The immune system requires a homeostatic equilibrium between the mechanisms that
assure self-tolerance, those that control the capacity to mount life-long immunity to …