Publisher Summary This chapter elaborates the regulation of the coronary microcirculation
under physiological and pathophysiological conditions. Many possibilities and contributing …

The majority of studies axamining the regulation of coronary blood flow and vascular
resistance have considered the coronary circulation as being composed of large conduit …

The coronary microcirculation regulates blood flow by responding to increased cardiac
metabolic demands. Despite this important role, study of the microcirculation has been …

Until recently, the majority of studies examining the regulation of coronary vascular
resistance have considered the coronary microcirculation as a single homogeneous …

The technology is available for the study of the coronary microcirculation in vivo and in vitro.
Coronary microvascular resistance depends continually upon intrinsic and extrinsic …

The coronary microvasculature is responsible for providing oxygen and nutrients to
myocardial tissue. A healthy microvasculature with an intact and properly functioning …

The coronary circulation, responsible for the delivery of oxygen and other nutrients to the
myocardium, is a complex system of conductance and resistance vessels. Each has its own …

Coronary reserve plays an important role in myocardial oxygen supply. During rest, oxygen
consumption is near to maximal. An increase in myocardial oxygen demand can only be …

Regulation of coronary microvascular resistance is not distributed uniformly, but varies
across different segments of the vasculature. Differences in regulatory mechanisms …

Coronary blood flow is closely regulated to meet the changing metabolic demands of the
working myocardium. Resistance of the coronary vasculature is determined by metabolic …