Th-17 type immune response that occurs in multiple sclerosis (MS) is linked to CCR6-
CCL20 interaction. We confirmed the dependency on CCR6 in EAE development …

CCL19 and CCL21 are thought to be critical for experimental autoimmune
encephalomyelitis (EAE) induction, but their precise role is unknown. We examined the role …

ABSTRACT EAE is a demyelinating disease of the CNS and serves as a mouse model of
MS. Expression of CCL22 in the draining LNs and spinal cord correlated with the onset of …

Chemokines are a superfamily of chemotactic cytokines that play an important role in
leukocyte trafficking and have been implicated as functional mediators of immunopathology …

Multiple sclerosis is an autoimmune disease in which the immune system attacks the nerve
myelin sheath. The balance between pathogenic Th17 cells and regulatory Treg cells, both …

Abstract Chemokine ligand 26 (CCL26) is a member of the eotaxin family. It works by
interacting exclusively with chemokine receptor 3 (CCR3) and acts as an eosinophil …

Chemokines and chemokine receptors play important roles in the immune response. We
previously reported the pathogenic role of CC chemokine receptor type 4 (CCR4) in …

Experimental autoimmune encephalomyelitis (EAE) is a Tcell-mediated autoimmune
disease of the CNS that is widely used as an animal model of multiple sclerosis. In this …

CCL19 and CCL21 bind to CCR7, which is crucial for both inducing an immune response
and establishing immunological tolerance. We report that in the normal human brain CCL19 …

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system. The
disease manifestation is associated with the proliferation and activation of lymphocytes and …