Primary biliary cirrhosis (PBC) is a chronic autoimmune cholestatic liver disease that
manifests a latitudinal gradient in prevalence and incidence. The mechanisms leading to the …

The etiology of primary biliary cirrhosis (PBC) is enigmatic, although it is clearly related to a
combination of genetic predisposition and environmental stimulation. PBC is a chronic …

Primary biliary cirrhosis is an autoimmune disease of unknown etiology leading to
progressive destruction of small intrahepatic bile ducts and eventually to liver cirrhosis and …

Primary biliary cirrhosis (PBC) is a chronic and slowly progressive cholestatic liver disease
of autoimmune etiology, characterized by injury of the intrahepatic bile ducts that may …

Primary biliary cirrhosis (PBC) is an autoimmune cholestatic liver disease. Susceptibility to
PBC probably arises from a combination of genetic and environmental factors. The …

The most difficult issue in autoimmunity remains etiology. Although data exist on effector
mechanisms in many autoimmune diseases, the underlying cause or causes are still …

Primary biliary cirrhosis (PBC) is an organ-specific autoimmune disease that predominantly
affects women and is characterized by chronic, progressive destruction of small intrahepatic …

Primary biliary cirrhosis (PBC) is a progressive cholestatic liver disease serologically
characterized by the presence of high-titer antimitochondrial antibodies and, histologically …

Primary biliary cirrhosis (PBC) is an idiopathic chronic autoimmune liver disease that
primarily affects women. It is believed that the aetiology for PBC is a combination between …

Primary biliary cirrhosis is an autoimmune cholestatic liver disease characterized by
humoral and cellular response directed at mitochondrial autoantigens, mainly the E2 …