Recent advance of nanoparticle-based topical drug delivery to the posterior segment of the eye

Y Wang, X Xu, Y Gu, Y Cheng, F Cao - Expert opinion on drug …, 2018 - Taylor & Francis
Introduction: Considering that the number of patients afflicted by posterior eye diseases is
increasing, effective drug delivery is currently in high clinical demand. Topical administration …

A review of nanocarrier-mediated drug delivery systems for posterior segment eye disease: Challenges analysis and recent advances

R Wang, Y Gao, A Liu, G Zhai - Journal of drug targeting, 2021 - Taylor & Francis
Posterior segment eye disease is a leading cause of irreversible vision impairment and
blindness. As the unique organ for vision, eyes are protected by various protective barriers …

Nanoparticles for drug delivery to the anterior segment of the eye

DR Janagam, L Wu, TL Lowe - Advanced drug delivery reviews, 2017 - Elsevier
Commercially available ocular drug delivery systems are effective but less efficacious to
manage diseases/disorders of the anterior segment of the eye. Recent advances in …

Nanotherapy for posterior eye diseases

IP Kaur, S Kakkar - Journal of Controlled Release, 2014 - Elsevier
It is assumed that more than 50% of the most enfeebling ocular diseases have their origin in
the posterior segment. Furthermore, most of these diseases lead to partial or complete …

Recent advances in topical nano drug-delivery systems for the anterior ocular segment

P Lakhani, A Patil, S Majumdar - Therapeutic delivery, 2018 - Taylor & Francis
Over the past decade, there has been a rise in the number of clinical cases of moderate to
severe anterior segment ocular diseases. Conventional topical ophthalmic formulations …

When nanotechnology meets the ocular surface

C Bucolo, A Maltese, F Drago - Expert Review of Ophthalmology, 2008 - Taylor & Francis
Controlled and sustained delivery of drugs for ophthalmic diseases continues to remain a
major challenge in the field of pharmaceutical drug delivery. To overcome the problems of …

[HTML][HTML] Lipid-based nanocarriers as topical drug delivery systems for intraocular diseases

J Navarro-Partida, CR Castro-Castaneda… - Pharmaceutics, 2021 - mdpi.com
Effective drug delivery to intraocular tissues remains a great challenge due to complex
anatomical and physiological barriers that selectively limit the entry of drugs into the eye. To …

Trends in formulation approaches for sustained drug delivery to the posterior segment of the eye

A Biswas, AD Choudhury, AC Bisen, S Agrawal… - AAPS …, 2023 - Springer
The eye, an intricate organ comprising physical and physiological barriers, poses a
significant challenge for ophthalmic physicians seeking to treat serious ocular diseases …

Drug delivery systems to the posterior segment of the eye: implants and nanoparticles

A Sepahvandi, M Eskandari, F Moztarzadeh - BioNanoScience, 2016 - Springer
Intraocular diseases in some cases lead to surgical treatment of posterior segments of the
eye. In addition, lack of effective treatment culminates in partial or complete blindness in …

[HTML][HTML] Ocular drug delivery barriers—role of nanocarriers in the treatment of anterior segment ocular diseases

RD Bachu, P Chowdhury, ZHF Al-Saedi, PK Karla… - Pharmaceutics, 2018 - mdpi.com
Ocular drug delivery is challenging due to the presence of anatomical and physiological
barriers. These barriers can affect drug entry into the eye following multiple routes of …