Abstract Receptor Tyrosine Kinase (RTK) endocytosis-dependent signalling drives cell
proliferation and motility during development and adult homeostasis, but is dysregulated in …

A fascinating conundrum in cell signaling is how stimulation of the same receptor tyrosine
kinase with distinct ligands generates specific outcomes. To decipher the functional …

Breast cancer stem cells (BCSCs) are unique in their ability to undergo unlimited self-
renewal, an essential process in breast cancer recurrence following metastatic dormancy …

Phosphatidylinositol 3‐phosphate (PtdIns3P) orchestrates endosomal cargo transport,
fusion and motility by recruiting FYVE or PX domain‐containing effector proteins to …

Through a network of progressively maturing vesicles, the endosomal system connects the
cell's interior with extracellular space. Intriguingly, this network exhibits a bilateral …

The fibroblast growth factor receptors (FGFRs) are important oncogenes promoting tumor
progression in many types of cancer, such as breast, bladder, and lung cancer as well as …

During nutrient stress, macroautophagy degrades cellular macromolecules, thereby
providing biosynthetic building blocks while simultaneously remodelling the proteome …

Phosphoproteomics can provide insights into cellular signaling dynamics. To achieve deep
and robust quantitative phosphoproteomics profiling for minute amounts of sample, we here …

Deregulation of autophagy has been linked to multiple degenerative diseases and cancer,
thus the identification of novel autophagy regulators for potential therapeutic intervention is …

The ubiquitin‒proteasome system (UPS) and autophagy are the two primary cellular
pathways of misfolded or damaged protein degradation that maintain cellular proteostasis …