Epigenetic regulation has long been recognized as a significant factor in various biological
processes, such as development, transcriptional regulation, spermatogenesis, and …

At present, understanding of DNA methylation at the population level is still limited. Here, we
first extended the classical framework of population genetics, such as single nucleotide …

DNA methylation, the most intensively studied epigenetic modification, plays an important
role in understanding the molecular basis of diseases. Furthermore, epigenome-wide …

Epigenetics is one of the most rapidly expanding fields in biomedical research, and the
popularity of the high-throughput next-generation sequencing (NGS) highlights the …

The assessment of expression and epigenomic status using sequencing based methods
provides an unprecedented opportunity to identify and correlate allelic differences with …

Motivation The identification of enhancer–promoter interactions (EPIs), especially condition-
specific ones, is important for the study of gene transcriptional regulation. Existing …

Cancer is a disease that is characterized by uncontrolled cell growth with the ability to
penetrate or develop to the other parts of the body. Various studies have shown the …

Epigenetics has recently emerged as a critical field for studying how non-gene factors can
influence the traits and functions of an organism. At the core of this new wave of research is …

Enhancer–promoter regulation is a fundamental mechanism underlying differential
transcriptional regulation. Spatial chromatin organization brings remote enhancers in …

As a pathological condition, epilepsy is caused by abnormal neuronal discharge in brain
which will temporarily disrupt the cerebral functions. Epilepsy is a chronic disease which …