Abstract Psychostimulant Use Disorder (PUD) is a chronic relapsing disorder with high
motivation for drug abuse. In addition to developing PUD, the use of psychostimulants is a …

Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system
that guides developmental and experience-dependent changes in many cellular substrates …

A primary feature of drug addiction is the compulsive use despite negative consequences. A
general consensus is emerging on the capacity of addictive substances to co-opt synaptic …

Addiction is an enormous societal problem. A number of recent studies have focused on
adaptations at glutamatergic synapses that may play a role in the behavioral responses to …

Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors and are
densely expressed in medium spiny projection neurons of striatum. Emerging evidence …

Protein phosphorylation is an important posttranslational modification of group I
metabotropic glutamate receptors (mGluR1 and mGluR5 subtypes) which are widely …

Addiction results from drug-elicited alterations of synaptic plasticity mechanisms in
dopaminergic reward circuits. Impaired metabotropic glutamate receptor (mGluR) …

Post-translational covalent modifications of glutamate receptors remain a hot topic. Early
studies have established that this family of receptors, including almost all ionotropic and …

Repeated cocaine produces enduring neuroadaptations in glutamate transmission in the
nucleus accumbens that are thought to contribute to addiction. Group II metabotropic …

Drugs of abuse modify synaptic long-term potentiation and long-term depression (LTD) in
the nucleus accumbens, and the impairment of synaptic plasticity in this brain region may be …