Left ventricular remodeling is a key determinant of the clinical course and outcome of
systolic heart failure. The myocardial renin–angiotensin system (RAS) has been closely …

Left ventricular (LV) remodeling constitutes the final common pathway for the progression of
systolic dysfunction to end-stage heart failure (HF)[1, 2]. The renin–angiotensin system …

Congestive heart failure is a pathologic condition characterized by progressive decrease in
left ventricular contractility and consequent decline of cardiac output. There is convincing …

Cardiac left ventricular (LV) remodeling is the final common pathway of most primary
cardiovascular diseases that manifest clinically as heart failure (HF). The more advanced the …

Objectives: The purpose of this study was to evaluate the feasibility of noninvasive imaging
of angiotensin II (AT) receptor upregulation in a mouse model of post-myocardial infarction …

Heart failure is a clinical syndrome caused by structural cardiac abnormalities that lead to
increased intracardiac pressures and decreased cardiac output. Following cardiovascular …

Left ventricular (LV) remodeling is a major determinant of the clinical course and outcome of
systolic heart failure (HF). Activation of neurohormonal and inflammatory cytokine pathways …

Conclusions Noninvasive imaging of neurohumoral upregulation in remodeled myocardium
suggests that an imaging strategy can be developed for predicting the rate of remodeling …

In response to injury, hemodynamic changes, or neurohormonal activation, the heart
undergoes a series of structural and functional changes that have been termed cardiac …

Clinical research during the past several decades has shown the importance of cardiac
remodeling as a basic mechanism in the progression of heart failure. Changes in cardiac …