A review of the genomics of neonatal abstinence syndrome

E Yen, N Gaddis, L Jantzie, JM Davis - Frontiers in Genetics, 2023 - frontiersin.org
Neonatal abstinence syndrome (NAS) is a constellation of signs of withdrawal occurring
after birth following in utero exposure to licit or illicit opioids. Despite significant research and …

The genetics and epigenetics of neonatal abstinence syndrome

EM Wachman, LA Farrer - Seminars in Fetal and Neonatal Medicine, 2019 - Elsevier
Neonatal abstinence syndrome (NAS) due to in-utero opioid exposure is a growing
epidemic with significant variability in clinical presentation and severity. Currently, NAS …

The genomics of neonatal abstinence syndrome

FS Cole, DJ Wegner, JM Davis - Frontiers in Pediatrics, 2017 - frontiersin.org
Significant variability has been observed in the development and severity of neonatal
abstinence syndrome (NAS) among neonates exposed to prenatal opioids. Since maternal …

Neonatal abstinence syndrome: twins Case series

R Pandey, N Pandey Sapkota, D Kumar - Frontiers in Pediatrics, 2017 - frontiersin.org
Background Use or abuse of opioids and related drugs during pregnancy increases the risk
of maternal and neonatal morbidities, including increased susceptibility to Neonatal …

Polygenic risk scores and the need for pharmacotherapy in neonatal abstinence syndrome

S Bibi, N Gaddis, EO Johnson, BM Lester, W Kraft… - Pediatric …, 2023 - nature.com
Background The aim of this study was to identify genetic variants associated with NAS
through a genome-wide association study (GWAS) and estimate a Polygenic Risk Score …

Understanding the effects of opioids vs non-opioids in the treatment of neonatal abstinence syndrome, an in vitro model

T Sithisarn, SJ Legan, PM Westgate, HS Bada… - Frontiers in …, 2022 - frontiersin.org
Neonatal abstinence syndrome (NAS) refers to cadre of withdrawal manifestations in infants
born to mothers who used illicit and licit substances during pregnancy. The increasing …

Neonatal abstinence syndrome: pharmacologic strategies for the mother and infant

WK Kraft, MW Stover, JM Davis - Seminars in Perinatology, 2016 - Elsevier
Opioid use in pregnancy has increased dramatically over the past decade. Since prenatal
opioid use is associated with numerous obstetrical and neonatal complications, this now has …

Neonatal abstinence syndrome: advances in diagnosis and treatment

EM Wachman, DM Schiff, M Silverstein - Jama, 2018 - jamanetwork.com
Importance Neonatal abstinence syndrome, which occurs as a result of in utero opioid
exposure, affects between 6.0 and 20 newborns per 1000 live US births. There is substantial …

Future newborns with opioid-induced Neonatal Abstinence Syndrome (NAS) could be assessed with the Genetic Addiction Risk Severity (GARS) test and potentially …

M Ceccanti, K Blum, A Bowirrat, CA Dennen… - Journal of Personalized …, 2022 - mdpi.com
In this nonsystematic review and opinion, including articles primarily selected from PubMed,
we examine the pharmacological and nonpharmacological treatments of neonatal …

Neonatal abstinence syndrome: review of epidemiology, care models, and current understanding of outcomes

KDL MacMillan - Clinics in perinatology, 2019 - perinatology.theclinics.com
Background Neonatal abstinence syndrome (NAS) includes an array of symptoms impacting
opioid-exposed newborns (OEN) owing to postnatal withdrawal from in utero substance …