Yeast-based virus-like particles as an emerging platform for vaccine development and delivery

V Srivastava, KN Nand, A Ahmad, R Kumar - Vaccines, 2023 - mdpi.com
Virus-like particles (VLPs) are empty, nanoscale structures morphologically resembling
viruses. Internal cavity, noninfectious, and particulate nature with a high density of repeating …

Yeast-based vaccines: New perspective in vaccine development and application

R Kumar, P Kumar - FEMS yeast Research, 2019 - academic.oup.com
In presently licensed vaccines, killed or attenuated organisms act as a source of
immunogens except for peptide-based vaccines. These conventional vaccines required a …

Yeast as an expression system for producing virus‐like particles: what factors do we need to consider?

HJ Kim, HJ Kim - Letters in applied microbiology, 2017 - academic.oup.com
The development of various types of virus‐like particles (VLPs) has accelerated over the
past two decades as the importance of VLPs for generating next‐generation vaccines has …

Virus-like particles: the future of microbial factories and cell-free systems as platforms for vaccine development

WA Rodríguez-Limas, K Sekar, KEJ Tyo - Current opinion in biotechnology, 2013 - Elsevier
Highlights▶ Microorganisms are inexpensive platforms to produce chimeric VLPs.▶
Bacteriophage-derived VLPs are excellent structures for drug delivery.▶ Microbial cell …

RNA vaccines: yeast as a novel antigen vehicle

AJD Silva, MMG de Sousa, LS de Macêdo… - Vaccines, 2023 - mdpi.com
In the last decades, technological advances for RNA manipulation enabled and expanded
its application in vaccine development. This approach comprises synthetic single-stranded …

Exploiting virus-like particles as innovative vaccines against emerging viral infections

H Jeong, BL Seong - Journal of Microbiology, 2017 - Springer
Emerging viruses pose a major threat to humans and livestock with global public health and
economic burdens. Vaccination remains an effective tool to reduce this threat, and yet, the …

Yeasts as a promising delivery platform for DNA and RNA vaccines

AJD Silva, LS de Macêdo, LRS Leal… - FEMS yeast …, 2021 - academic.oup.com
Yeasts are considered a useful system for the development of vaccines for human and
veterinary health. Species such as Saccharomyces cerevisiae and Pichia pastoris have …

Production of virus-like particles for vaccines

J Fuenmayor, F Gòdia, L Cervera - New biotechnology, 2017 - Elsevier
Virus-like particles (VLPs) are nanostructures that resemble the structures of viruses. They
are composed of one or more structural proteins that can be arranged in several layers and …

Virus-like particles as antiviral vaccine: mechanism, design, and application

L Zhang, W Xu, X Ma, XJ Sun, JB Fan… - Biotechnology and …, 2023 - Springer
Virus-like particles (VLPs) are viral structural protein that are noninfectious as they do not
contain viral genetic materials. They are safe and effective immune stimulators and play …

Recent progress on the versatility of virus-like particles

C Qian, X Liu, Q Xu, Z Wang, J Chen, T Li, Q Zheng… - Vaccines, 2020 - mdpi.com
Virus-like particles (VLPs) are multimeric nanostructures composed of one or more structural
proteins of a virus in the absence of genetic material. Having similar morphology to natural …