[HTML][HTML] Single-cell analysis of the developing human testis reveals somatic niche cell specification and fetal germline stem cell establishment
Human testis development in prenatal life involves complex changes in germline and
somatic cell identity. To better understand, we profiled and analyzed∼ 32,500 single-cell …
somatic cell identity. To better understand, we profiled and analyzed∼ 32,500 single-cell …
The adult human testis transcriptional cell atlas
Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and
differentiation, alongside complex germ cell-niche interactions, to ensure long-term fertility …
differentiation, alongside complex germ cell-niche interactions, to ensure long-term fertility …
The neonatal and adult human testis defined at the single-cell level
Spermatogenesis has been intensely studied in rodents but remains poorly understood in
humans. Here, we used single-cell RNA sequencing to analyze human testes. Clustering …
humans. Here, we used single-cell RNA sequencing to analyze human testes. Clustering …
[HTML][HTML] The dynamic transcriptional cell atlas of testis development during human puberty
The human testis undergoes dramatic developmental and structural changes during
puberty, including proliferation and maturation of somatic niche cells, and the onset of …
puberty, including proliferation and maturation of somatic niche cells, and the onset of …
Transcription and imprinting dynamics in developing postnatal male germline stem cells
Postnatal spermatogonial stem cells (SSCs) progress through proliferative and
developmental stages to populate the testicular niche prior to productive spermatogenesis …
developmental stages to populate the testicular niche prior to productive spermatogenesis …
Mapping lineage progression of somatic progenitor cells in the mouse fetal testis
C Liu, K Rodriguez, HHC Yao - Development, 2016 - journals.biologists.com
Testis morphogenesis is a highly orchestrated process involving lineage determination of
male germ cells and somatic cell types. Although the origin and differentiation of germ cells …
male germ cells and somatic cell types. Although the origin and differentiation of germ cells …
The germline stem cell niche unit in mammalian testes
JM Oatley, RL Brinster - Physiological reviews, 2012 - journals.physiology.org
This review addresses current understanding of the germline stem cell niche unit in
mammalian testes. Spermatogenesis is a classic model of tissue-specific stem cell function …
mammalian testes. Spermatogenesis is a classic model of tissue-specific stem cell function …
A comprehensive roadmap of murine spermatogenesis defined by single-cell RNA-seq
Spermatogenesis requires intricate interactions between the germline and somatic cells.
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …
Functional and molecular features of the Id4+ germline stem cell population in mouse testes
F Chan, MJ Oatley, AV Kaucher, QE Yang… - Genes & …, 2014 - genesdev.cshlp.org
The maintenance of cycling cell lineages relies on undifferentiated subpopulations
consisting of stem and progenitor pools. Features that delineate these cell types are …
consisting of stem and progenitor pools. Features that delineate these cell types are …
Building the mammalian testis: origins, differentiation, and assembly of the component cell populations
Development of testes in the mammalian embryo requires the formation and assembly of
several cell types that allow these organs to achieve their roles in male reproduction and …
several cell types that allow these organs to achieve their roles in male reproduction and …