The nervous and immune systems control whole-body homeostasis and respond to various
types of tissue injury, including stroke, in a coordinated manner. Cerebral ischaemia and …

Immune and inflammatory responses actively modulate the pathophysiological processes of
acute brain injuries such as stroke. Soon after the onset of stroke, signals such as brain …

Stroke is the world's leading cause of disability with limited brain repair treatments which
effectively improve long‐term neurological deficits. The neuroinflammatory responses …

Following a cerebral ischemic event, substantial alterations in both cellular and molecular
activities occur due to ischemia-induced cerebral pathology. Mounting evidence indicates …

Stroke is a leading cause of mortality and long-term disability worldwide, with limited
spontaneous repair processes occurring after injury. Immune cells are involved in multiple …

The inflammatory and immunological responses play a significant role after stroke. The
innate immune activation stimulated by microglia during stroke results in the migration of …

The immune system is rapidly activated after ischemic stroke. As immune cells migrate and
infiltrate across the blood-brain barrier into the ischemic region, a cascade of cellular and …

The immune response to stroke is an exciting target for future stroke therapies. Stroke is a
leading cause of morbidity and mortality worldwide, and clot removal (mechanical or …

Despite extensive research into stroke pathology, there have not been any major recent
advancements in stroke therapeutics. Animal models of cerebral ischemia and clinical data …

Stroke disrupts the homeostatic balance within the brain and is associated with a significant
accumulation of necrotic cellular debris, fluid, and peripheral immune cells in the central …