Tissue preparation for histologic evaluation of bone is particularly lengthy, limiting its use in
intraoperative or intraprocedural histological evaluation. Nonlinear microscopy (NLM) is an …

Rapid histological assessment of large areas of prostate tissue is required for many
intraoperative consultation scenarios such as margin evaluation. Nonlinear microscopy …

Rapid intraoperative assessment of breast excision specimens is clinically important
because up to 40% of patients undergoing breast-conserving cancer surgery require …

Bone tissue features a complex microarchitecture and biomolecular composition, which
determine biomechanical properties. In addition to state-of-the-art technologies, innovative …

Intraoperative evaluation of specimens during radical prostatectomy using frozen sections
can be time and labor intensive. Nonlinear microscopy (NLM) is a fluorescence microscopy …

Objectives Traditional histopathology is a time-intensive and labor-intensive process
involving tissue formalin fixation, paraffin embedding, and microtoming into thin sections for …

OBJECTIVE: To assess the ability of nonlinear optical microscopy (NLOM) to image ex vivo
healthy and degenerative bovine articular cartilage. METHOD: Fresh bovine femoral–tibial …

Microscopy of bony tissue usually requires special treatment for decalcification and
processing of thin sections. Confocal laser scanning microscopy (CLSM) allows the …

An estimated 1.3 million people in the United States suffer from rheumatoid arthritis (RA). RA
causes profound changes in the synovial membrane of joints, and without early diagnosis …

Previous studies using nonlinear microscopy have demonstrated that osteoarthritis (OA) is
characterized by the gradual replacement of Type II collagen with Type I collagen. The …