During the last decade there has been a growing interest in glycoimmunology, a relatively
new research field dealing with the specific interactions of carbohydrates with the immune …

Conspectus Since 2004, when the first synthetic glycoconjugate vaccine against the
pneumonia and meningitis causing bacterium Haemophilus influenza type b (Hib) approved …

Glycoconjugate vaccines obtained by chemical linkage of a carbohydrate antigen to a
protein are part of routine vaccinations in many countries. Licensed antimicrobial glycan …

Carbohydrates are often found linked to lipids or proteins, to form glycoconjugates such as
glycolipids, glycoproteins and proteoglycans. These glycoconjugates play important …

Vaccinations provide an efficient and cost-effective way to combat devastating human
diseases. Besides pathogenic protein markers, cell surface carbohydrates from biological …

Vaccination is a key strategy for the control of various infectious diseases. Many pathogens,
such as Streptococcus pneumoniae, Haemophilus influenzae type b (Hib), and Neisseria …

Vaccination is the most cost-efficient and the most powerful medical intervention in the
control, prevention and eradication of many diseases that affect human population. Capsular …

Licensed carbohydrate-based vaccines are obtained by conjugation of native or sized
polysaccharides to an appropriate carrier protein. They are part of routine vaccinations in …

The glycocalyx, a thick layer of carbohydrates, surrounds the cell wall of most bacterial and
parasitic pathogens. Recognition of these unique glycans by the human immune system …

Highlights•Developments in carbohydrate antigen synthesis expand potential disease
targets.•Both protein and lipid carriers can enhance immune responses against …