Depression is the leading cause of disease burden globally. Existing antidepressant
treatments that target the central nervous system have limited efficacy and come at the cost …

Current theories suggest that the brain is the sole source of mental illness. However,
affective disorders, and major depressive disorder (MDD) in particular, may be better …

Major depressive disorder is the leading cause of disability worldwide. Currently available
pharmacological approaches to the treatment of depression (which are the mainstay of …

Objectives: Accumulating evidence suggests that individuals with depression are
characterised by difficulties in thermoregulatory cooling. The aim of this study was to …

Objectives: Sweating, hot flushes, and blushing are symptoms frequently reported by
individuals with anxiety disorders. They represent important reinforcers of anxiogenic …

Evidence suggests that affective disorders are associated with altered thermoregulation, and
it has been hypothesized that therapeutic strategies targeting body-to-brain thermosensory …

There is urgent need for novel antidepressant treatments that confer therapeutic benefits via
engagement with identified mechanistic targets. The objective of the study was to determine …

Objective Passive body heating can have an antidepressant effect by activating warm-
sensitive neural pathways associated with affective functions. Interventional studies showed …

We studied how sympathetic response to cold exposure determines thermoregulatory
function. Three female and seven male volunteers (age, 23.2±1.9 years) were exposed to …

Correlations between altered body temperature and depression have been reported in small
samples; greater confidence in these associations would provide a rationale for further …