Protective effect of sulforaphane against oxidative stress: recent advances

CE Guerrero-Beltrán, M Calderón-Oliver… - Experimental and …, 2012 - Elsevier
Sulforaphane [1-isothiocyanate-(4R)-(methylsulfinyl) butane] is a natural dietary
isothiocyanate produced by the enzymatic action of the myrosinase on glucopharanin, a 4 …

Sulforaphane protects against cytokine-and streptozotocin-induced β-cell damage by suppressing the NF-κB pathway

MY Song, EK Kim, WS Moon, JW Park, HJ Kim… - Toxicology and applied …, 2009 - Elsevier
Sulforaphane (SFN) is an indirect antioxidant that protects animal tissues from chemical or
biological insults by stimulating the expression of several NF-E2-related factor-2 (Nrf2) …

Cytotoxic and antitumor activity of sulforaphane: the role of reactive oxygen species

P Sestili, C Fimognari - BioMed Research International, 2015 - Wiley Online Library
According to recent estimates, cancer continues to remain the second leading cause of
death and is becoming the leading one in old age. Failure and high systemic toxicity of …

[PDF][PDF] Potential health benefits of sulforaphane: a review of the experimental, clinical and epidemiological evidences and underlying mechanisms

F Elbarbry, N Elrody - J Med Plants Res, 2011 - academicjournals.org
Extensive epidemiological evidence and animal experimental studies suggest that
cruciferous vegetables may prevent or delay various inflammatory disorders, including …

Potent induction of total cellular and mitochondrial antioxidants and phase 2 enzymes by cruciferous sulforaphane in rat aortic smooth muscle cells: cytoprotection …

H Zhu, Z Jia, JS Strobl, M Ehrich, HP Misra… - Cardiovascular …, 2008 - Springer
Sulforaphane, a cruciferous isothiocyanate compound, upregulates cytoprotective genes in
liver, but its effects on antioxidants and phase 2 defenses in vascular cells are unknown …

Isothiocyanate from broccoli, sulforaphane, and its properties

A Vanduchova, P Anzenbacher… - Journal of medicinal …, 2019 - liebertpub.com
Sulforaphane is an isothiocyanate occurring in stored form as glucoraphanin in cruciferous
vegetables such as cabbage, cauliflower, and kale, and at high levels in broccoli especially …

[PDF][PDF] Current potential health benefits of sulforaphane

JK Kim, SU Park - 2016 - 129.217.131.68
Sulforaphane [SFN: 1-isothiocyanato-4-(methylsulfinyl) butane] belongs to the
isothiocyanate class of phytochemicals. Glucoraphanin, a glucosinolate precursor of SFN, is …

Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma …

MK Kwak, JM Cho, B Huang, S Shin… - Free Radical Biology and …, 2007 - Elsevier
The 26S proteasome is responsible for degradation of abnormal proteins and may play a
role in cell survival upon oxidative stress. The indirect antioxidant sulforaphane (SFN) …

[HTML][HTML] Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes

JW Fahey, P Talalay - Food and chemical toxicology, 1999 - Elsevier
The widespread belief that oxidative damage plays a major role in cancer, ageing, and in a
number of chronic diseases has focused scientific and public attention on the possibility that …

Anticancer activity of sulforaphane: the epigenetic mechanisms and the Nrf2 signaling pathway

X Su, X Jiang, L Meng, X Dong… - Oxidative medicine and …, 2018 - Wiley Online Library
Sulforaphane (SFN), a compound derived from cruciferous vegetables that has been shown
to be safe and nontoxic, with minimal/no side effects, has been extensively studied due to its …