Ghrelin and the short-and long-term regulation of appetite and body weight

DE Cummings - Physiology & behavior, 2006 - Elsevier
Ghrelin, an acylated upper gastrointestinal peptide, is the only known orexigenic hormone.
Considerable evidence implicates ghrelin in mealtime hunger and meal initiation …

[HTML][HTML] Regulation of ghrelin in physiologic and pathophysiologic states

DL Williams, DE Cummings - The Journal of nutrition, 2005 - Elsevier
Ghrelin, a ligand for the growth hormone secretagogue receptor, is an orexigenic hormone
produced in the gastrointestinal tract. In humans and other animals, circulating ghrelin levels …

Ghrelin and energy balance: focus on current controversies

DE Cummings, KE Foster-Schubert… - Current drug …, 2005 - ingentaconnect.com
Ghrelin is an enteric peptide that is the only known circulating appetite stimulant. This
feature of the hormone has garnered widespread attention, as reflected by more than 1000 …

Euglycemic hyperinsulinemia, but not lipid infusion, decreases circulating ghrelin levels in humans

M Möhlig, J Spranger, B Otto, M Ristow… - Journal of …, 2002 - Springer
The orexigenic and anabolic gastric hormone ghrelin is secreted in response to acute and
chronic energy requirements. While pre-prandial increases and post-prandial decreases of …

Ghrelin—not just another stomach hormone

G Wang, HM Lee, E Englander, GH Greeley Jr - Regulatory Peptides, 2002 - Elsevier
Growth hormone (GH) secretagogues (GHSs) are non-natural, synthetic substances that
stimulate GH secretion via a G-protein-coupled receptor called the GHS-receptor (GHS-R) …

Role of the duodenum and macronutrient type in ghrelin regulation

J Overduin, RS Frayo, HJ Grill, JM Kaplan… - …, 2005 - academic.oup.com
The orexigenic hormone ghrelin is implicated in preprandial hunger and meal initiation in
part because circulating levels increase before meals and decrease after food intake. The …

Biological, physiological, and pharmacological aspects of ghrelin

H Hosoda, M Kojima, K Kangawa - Journal of pharmacological …, 2006 - jstage.jst.go.jp
Ghrelin, identified as an endogenous ligand for the growth hormone secretagogue receptor,
functions as a somatotrophic and orexigenic signal from the stomach. Ghrelin has a unique …

Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status

DL Drazen, TP Vahl, DA D'Alessio, RJ Seeley… - …, 2006 - academic.oup.com
Circulating levels of the orexigenic peptide ghrelin increase during fasting and decrease
with refeeding. Exogenous ghrelin administration is a potent stimulus for food intake in …

Ghrelin in the regulation of body weight and metabolism

TR Castaneda, J Tong, R Datta, M Culler… - Frontiers in …, 2010 - Elsevier
Ghrelin, a peptide hormone predominantly produced by the stomach, was isolated as the
endogenous ligand for the growth hormone secretagogue receptor. Ghrelin is a potent …

The effect of ingested macronutrients on postprandial ghrelin response: a critical review of existing literature data

C Koliaki, A Kokkinos, N Tentolouris… - … journal of peptides, 2010 - Wiley Online Library
Ghrelin is a powerful orexigenic gut hormone with growth hormone releasing activity. It plays
a pivotal role for long‐term energy balance and short‐term food intake. It is also recognized …