BACKGROUND Smoke inhalation and burn injury remain a major source of morbidity and
mortality. There is known dysregulation of hemostasis in burn patients, but either …

Various studies have reported discordant results on the magnitude and direction of burn-
induced coagulopathy (BIC), which has recently been associated with multiple organ …

The role of platelet-activating factor (PAF) in inhalation injury was studied in sheep, using
CV-3988, a PAF antagonist. Following smoke exposure, 15 sheep were divided into three …

Burn and smoke inhalation-related multiple organ dysfunction is associated with a severe
fall in the plasma concentration of antithrombin. Therefore the aim of the present study was …

Burn injuries are common and often life-threatening trauma. With this trauma comes an
interruption of normal hemostasis, with distinct impacts on platelets. Our interest in the …

Burn-induced coagulopathy is not well understood, and consensus on diagnosis,
prevention, and treatments are lacking. In this review, literature on burn-induced (and …

BACKGROUND Hypercoagulability is a homeostatic response to trauma, but relatively little
information is available about coagulation changes after burn injury. Therefore, we tested …

Thrombin is involved in various inflammatory responses. In sepsis, coagulation
abnormalities are major complications. Acute lung injury is one of the most life-threatening …

BACKGROUND The pathophysiology and time course of coagulopathy after major burns are
inadequately understood. Our study objectives were to determine whether acute traumatic …

Methods Seven sheep (G1) received smoke injury alone; eight (G2) received a 40% full-
thickness scald burn immediately after smoke injury. All animals were resuscitated with …