Despite substantial attention from theoreticians, the evolutionary mechanisms that drive intra-
and interspecific variation in the mutation rate remain unclear. It has often been argued that …

As one of the few cellular traits that can be quantified across the tree of life, DNA-replication
fidelity provides an excellent platform for understanding fundamental evolutionary …

Mutation dictates the tempo and mode of evolution, and like all traits, the mutation rate is
subject to evolutionary modification. Here, we report refined estimates of the mutation rate …

Understanding the mechanisms of evolution requires information on the rate of appearance
of new mutations and their effects at the molecular and phenotypic levels. Although …

Mutation rate is one of the most fundamental parameters in genetics and evolutionary
biology because mutation rate has major impacts on the incidence of disease, the amount of …

Mutations are the ultimate source of variation used for evolutionary adaptation, while also
being predominantly deleterious and a source of genetic disorders. Understanding the rate …

We review recent advances in the understanding of the mutation-selection balance of
asexual replicators. For over 30 years, population geneticists thought that an expression …

The evolution of genotypic mutation rates has been investigated in numerous theoretical
and experimental studies. Mutations, however, occur not only when copying DNA, but also …

Rates of spontaneous mutation per genome as measured in the laboratory are remarkably
similar within broad groups of organisms but differ strikingly among groups. Mutation rates in …

Rates of molecular evolution are known to vary between species and across all kingdoms of
life. Here, we explore variation in the rate at which bacteria accumulate mutations …