Classical therapy of heart failure is based on treatment of its pre-disposing/triggering factors
and of the neurohumoral activation secondary to the deterioration of cardiac function. A new …

Given the lack of a unified theory of heart failure, future research efforts will be required to
unify and synthesize our current understanding of the multiple mechanisms that control …

Pathological molecular mechanisms involved in myocardial remodeling contribute to alter
the existing structure of the heart, leading to cardiac dysfunction. Among the complex …

The process of heart failure appears to be a common and coordinated response to cardiac
injury and dysfunction. The contemporary mechanistic viewpoint that predictable, shared …

Ventricular remodeling after myocardial infarction is defined as progressive chamber dilation
and wall thinning, which leads to functional compromise. Remodeling is mediated by active …

Abstract Purpose of Review In this review, we highlight the most important cellular and
molecular mechanisms that contribute to cardiac inflammation and fibrosis. We also discuss …

After myocardial infarction, remodeling of the left ventricle involves a wound-healing
orchestra involving a variety of cell types. In order for wound healing to be optimal …

As more patients survive myocardial infarctions, the incidence of heart failure increases.
After an infarction, the human heart undergoes a series of structural changes, which are …

Myocardial infarction is the most common form of acute cardiac injury attributing to heart
failure. While there have been significant advances in current therapies, mortality and …

Cardiac remodeling describes a series of structural and functional changes in the heart after
myocardial infarction (MI). Adverse post‐MI cardiac remodeling directly jeopardizes the …