Most life scientists would agree that understanding how cellular processes work requires
structural knowledge about the macromolecules involved. For example, deciphering the …

172| NATURE| VOL 525| 10 SEPTEMBER 2015© 2015 Macmillan Publishers Limited. All
rights reserved discoveries that leading journals are publishing at a rapid clip. Structural …

RESOLUTION FIXATION Protein structures are often judged by a single factor: resolution,
the level of detail a structure shows. That metric is straightforward to ascertain in …

Abstract Knowledge of the three-dimensional structures of proteins and other biological
macromolecules often aids understanding of how they perform complicated tasks in the cell …

Cryo-electron microscopy reaches atomic resolution Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

The Royal Swedish Academy of Sciences awarded the 2017 Nobel Prize for Chemistry to
Jacques Dubochet, Joachim Frank, and Richard Henderson for" developing cryoelectron …

Visualizing the dynamic molecular architecture of cells is instrumental for answering
fundamental questions in cellular and structural biology. Although modern microscopy …

Visualization of cellular processes at a resolution of the individual protein should involve
integrative and complementary approaches that can eventually draw realistic functional and …

The suddenness with which single-particle cryo-electron microscopy (cryo-EM) has
emerged as a method for determining high-resolution structures of biological …

Highlights•Electron cryo-tomography (cryoET) reveals structures in a near-native
state.•Recent technological advances have increased the information obtainable by …