Engineered microbes for the delivery of biologics are a promising avenue for the treatment
of various conditions such as chronic inflammatory disorders and metabolic disease. In this …

Effector memory T lymphocytes (T EM cells) that lack expression of CCR7 are major drivers
of inflammation in a number of autoimmune diseases, including multiple sclerosis and …

The voltage-gated Kv1. 3 K+ channel is a novel target for immunomodulation of autoreactive
effector memory T (TEM) cells that play a major role in the pathogenesis of autoimmune …

Abstract The peptide HsTX1 [R14A] is a potent and selective blocker of the voltage-gated
potassium channel Kv1. 3, a well-recognized therapeutic target for autoimmune diseases …

The Kv1. 3 channel is a recognized target for pharmaceutical development to treat
autoimmune diseases and organ rejection. ShK-186, a specific peptide inhibitor of Kv1. 3 …

Is it possible to enhance structural stability and biological activity of KR-12, a truncated
antimicrobial peptide derived from the human host defense peptide LL-37? Based on the …

Highlights•The K v 1.3 channel in T cells is a validated therapeutic target for autoimmune
diseases.•The most potent blockers are peptides from scorpions and sea anemones.•Phase …

Kv1. 3 potassium channels maintain the membrane potential of effector memory (TEM) T
cells that are important mediators of multiple sclerosis, type 1 diabetes mellitus, and …

Fibroblast-like synoviocytes (FLSs) are a key cell type involved in rheumatoid arthritis (RA)
progression. We previously identified the KCa1. 1 potassium channel (Maxi-K, BK, Slo 1 …

Klebsiella pneumoniae (Kp) is one of the most common pathogens in nosocomial infections
and is increasingly becoming multiple drug resistant. However, the molecular pathogenesis …