Plasma prekallikrein is the liver-derived precursor of the trypsin-like serine protease plasma
kallikrein (PK) and circulates in plasma bound to high molecular weight kininogen. The …

Plasma prekallikrein is the liver-derived precursor of the trypsin-like serine protease plasma
kallikrein, and circulates in plasma bound to high molecular weight kininogen. Plasma …

Human plasma kallikrein (PKa) is obtained by activating its precursor, prekallikrein (PK),
historically named the Fletcher factor. Human PKa and tissue kallikreins are serine …

The kallikrein kinin system (KKS) consists of serine proteases involved in the production of
peptides called kinins, principally bradykinin and Lys-bradykinin (kallidin). The KKS …

Essentials• Zymogen PK is activated to PKa and cleaves substrates kininogen and FXII
contributing to bradykinin generation.• Monomeric PKa and dimeric homologue FXI utilize …

Plasma kallikrein (PK) is a serine protease generated from plasma prekallikrein, an
abundant circulating zymogen expressed by the Klkb1 gene. The physiological actions of …

The plasma kallikrein-kinin system (KKS) plays a critical role in human physiology. The KKS
encompasses coagulation factor XII (FXII), the complex of prekallikrein (PK) and high …

F or forty years my laboratory has been studying the kallikrein-kininogen-kinin system (KKS).
I was challenged by my mentor Dr. Sol Sherry in whose laboratory I was completing my …

The plasma kallikrein–kinin system consists of the proteins factor XII (FXII), prekallikrein
(PK), and high molecular weight kininogen. It was first recognized as a surface‐activated …

Plasma kallikrein (pKal) proteolytically cleaves high molecular weight kininogen to generate
the potent vasodilator and the pro-inflammatory peptide, bradykinin. pKal activity is tightly …