Progresses over the past years have extensively improved our capacity to use genome-
scale analyses—including high-density genotyping and exome and genome sequencing …

Background Childhood cancer has a poorly known etiology, and investigating the
underlying genetic background may provide novel insights. A recognized association exists …

Developments over the past five years have significantly advanced our ability to use
genome-scale analyses—including high-density genotyping, transcriptome sequencing …

In childhood cancer, the frequency of cancer-associated germline variants and their
inheritance patterns are not thoroughly investigated. Moreover, the identification of children …

Simple Summary The idea that motivated the design of the project is to offer a genetic
germline analysis to all pediatric patients diagnosed in our pediatric oncology unit. The main …

Genetic predisposition is an important underlying cause of childhood cancer, although the
proportion of patients with childhood cancer carrying predisposing pathogenic germline …

Genetic predisposition to cancers in children and adolescent... : Current Opinion in
Pediatrics Genetic predisposition to cancers in children and adolescents : Current Opinion …

Abstract Geneticists estimate that 5% to 10% of all cancers diagnosed in the pediatric age
range occur in children born with a genetic mutation that directly increases their lifetime risk …

The acquisition of de novo somatic mutations accounts for approximately 90% of all new
cancer diagnoses, while the remaining 10% is due to inherited genetic traits. In this latter …

Simple Summary Here we provide an overview of several genetically determined conditions
that predispose to the development of solid and hematologic malignancies in children …