Introduction Thanks to new generation sequencing (NGS) and expansion of HLA typing with
additional loci, it will be possible to increase the effectiveness of graft survival and to avoid …

The HLA region is the most polymorphic genes in the human genome and is associated with
an increasing number of disease states. Historically, HLA typing methodology has been …

Although controversial, organ allocation on the basis of HLA matching has been widely
adopted in renal transplants. Since the discovery of HLA as the dominant histocompatibility …

Inthischapter, wewillexploretheeffectofhumanleukocyte antigen (HLA) matchingonrenal
transplant outcomes. The importance of HLA matching has been clearly established in renal …

The HLA system consists of a group of cell surface proteins encoded for by genes located on
the short arm of chromosome 6. Since the discovery of this system in the 1950s, it has …

Histocompatibility testing is an essential component of a successful kidney transplant
program for two fundamental reasons. First, human leukocyte antigens (HLA) play a central …

Introduction Antibody mediated rejection (ABMR) is the most common cause of long-term
allograft loss in kidney transplantation (KT). Therefore, a low human leukocyte antigen (HLA) …

EDITORIALS www. jasn. org medications used to prevent alloimmune injury also increase
the risk of the most common causes of death with function (ie, cardiac, infection, cancer). In …

Studies utilizing inferred second field high-resolution (2F-HR) HLA genotypes showed that
risk stratification in kidney transplantation can be better assessed at the HLA molecular …

HLA antigens are the major barrier to successful transplantation. Three of the seven
heterodimers (HLA-A,-B, and-DR) contribute most to the immunogenicity of a mismatched …