[HTML][HTML] Multifaceted role of the placental growth factor (PlGF) in the antitumor immune response and cancer progression

L Albonici, MG Giganti, A Modesti, V Manzari… - International Journal of …, 2019 - mdpi.com
The sharing of molecules function that affects both tumor growth and neoangiogenesis with
cells of the immune system creates a mutual interplay that impairs the host's immune …

[HTML][HTML] Role of placenta growth factor in cancer and inflammation

KJ Kim, CS Cho, WU Kim - Experimental & molecular medicine, 2012 - nature.com
Accumulating evidences have documented that angiogenesis is closely linked to
inflammation and regulators of angiogenesis play key roles in various inflammatory …

PlGF: a multitasking cytokine with disease-restricted activity

M Dewerchin, P Carmeliet - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF)
family that also comprises VEGF-A (VEGF), VEGF-B, VEGF-C, and VEGF-D. Unlike VEGF …

Placenta growth factor is over-expressed and has prognostic value in human breast cancer

C Parr, G Watkins, M Boulton, J Cai… - European Journal of …, 2005 - Elsevier
Placenta growth factor (PlGF) belongs to the vascular endothelial growth factor (VEGF)
family, a group of angiogenic factors that are crucial for tumour angiogenesis. Very little is …

Placental growth factor in cancer

M Dewerchin, P Carmeliet - Expert opinion on therapeutic targets, 2014 - Taylor & Francis
Introduction: Placental growth factor (PLGF) belongs to the VEGF family, which among the
three VEGF receptors binds exclusively to VEGFR1, present on various cell types. Isoform …

Vascular endothelial growth factor-dependent spatiotemporal dual roles of placental growth factor in modulation of angiogenesis and tumor growth

X Yang, Y Zhang, Y Yang, S Lim… - Proceedings of the …, 2013 - National Acad Sciences
Placental growth factor (PlGF) remodels tumor vasculatures toward a normalized phenotype,
which affects tumor growth, invasion and drug responses. However, the coordinative and …

Tumor cell-derived placental growth factor sensitizes antiangiogenic and antitumor effects of anti-VEGF drugs

EME Hedlund, X Yang, Y Zhang… - Proceedings of the …, 2013 - National Acad Sciences
The role of placental growth factor (PlGF) in modulation of tumor angiogenesis and tumor
growth remains an enigma. Furthermore, anti-PlGF therapy in tumor angiogenesis and …

Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells

YL Lin, YC Liang, BL Chiang - Journal of Leucocyte Biology, 2007 - academic.oup.com
Placental growth factor (PlGF) belongs to the vascular endothelial growth factor (VEGF)
family and represents a key regulator of angiogenic events in development and pathologic …

[HTML][HTML] PlGF immunological impact during pregnancy

L Albonici, M Benvenuto, C Focaccetti, L Cifaldi… - International Journal of …, 2020 - mdpi.com
During pregnancy, the mother's immune system has to tolerate the persistence of paternal
alloantigens without affecting the anti-infectious immune response. Consequently, several …

The significance of placenta growth factor in angiogenesis and clinical outcome of human gastric cancer

CN Chen, FJ Hsieh, YM Cheng, WF Cheng, YN Su… - Cancer letters, 2004 - Elsevier
Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF)
family of proangiogenic factors and its overexpression has been linked to pathological …