Development of carbohydrate based next-generation anti-pertussis vaccines
Pertussis is a highly contagious respiratory disease caused by the Gram-negative bacterial
pathogen, Bordetella pertussis. Despite high global vaccination rates, pertussis is resurging …
pathogen, Bordetella pertussis. Despite high global vaccination rates, pertussis is resurging …
Chemical synthesis and immunological evaluation of a pentasaccharide bearing multiple rare sugars as a potential anti‐pertussis vaccine
P Wang, C Huo, S Lang, K Caution, ST Nick… - Angewandte …, 2020 - Wiley Online Library
With the infection rate of Bordetella pertussis at a 60‐year high, there is an urgent need for
new anti‐pertussis vaccines. The lipopolysaccharide (LPS) of B. pertussis is an attractive …
new anti‐pertussis vaccines. The lipopolysaccharide (LPS) of B. pertussis is an attractive …
Bordetella pertussis lipooligosaccharide-derived neoglycoconjugates–new components of pertussis vaccine
S Koj, C Ługowski, T Niedziela - Advances in Hygiene and Experimental …, 2015 - phmd.pl
Pertussis is a contagious respiratory tract disease caused by the Gram-negative bacterium
Bordetella pertussis. Despite widespread vaccination, in recent years the pertussis …
Bordetella pertussis. Despite widespread vaccination, in recent years the pertussis …
[HTML][HTML] Structure and Immunogenicity of the Bordetella pertussis LOS-Derived Oligosaccharides in the Endosomal-Like Pre-Processing Mice Model
S Koj, K Ucieklak, C Lugowski, T Niedziela - Vaccines, 2021 - mdpi.com
Glycoproteins are processed endosomally prior to presentation to T cells and subsequent
induction of specific antibodies. The sugar part of glycoconjugate may be degraded while …
induction of specific antibodies. The sugar part of glycoconjugate may be degraded while …
[HTML][HTML] Oligosaccharide ligand tuning in design of third generation carbohydrate pneumococcal vaccines
YE Tsvetkov, ML Gening, EA Kurbatova… - Pure and Applied …, 2017 - degruyter.com
Streptococcus pneumoniae can cause many types of dangerous infectious diseases such as
otitis media, pneumonia, meningitis and others that are more common in the very young and …
otitis media, pneumonia, meningitis and others that are more common in the very young and …
[HTML][HTML] A novel vaccine formulation candidate based on lipooligosaccharides and pertussis toxin against Bordetella pertussis
J Gao, L Huang, S Luo, R Qiao, F Liu, X Li - Frontiers in Immunology, 2023 - frontiersin.org
Pertussis is a severe human respiratory tract infectious disease caused by Bordetella
pertussis that primarily affects infants and young children. However, the acellular pertussis …
pertussis that primarily affects infants and young children. However, the acellular pertussis …
Synthesis of oligosaccharides from terminal B. pertussis LPS pentasaccharide and definition of the minimal epitope recognized by anti-pertussis antibodies
G Chen, L Guo, J Huang, S Fernandez-Castillo… - Glycoconjugate …, 2024 - Springer
Pertussis vaccines have been very effective in controlling whooping-cough epidemics but
are ineffective in controlling circulation in older children and adults, thus facilitating the onset …
are ineffective in controlling circulation in older children and adults, thus facilitating the onset …
[HTML][HTML] Antimicrobial glycoconjugate vaccines: an overview of classic and modern approaches for protein modification
F Berti, R Adamo - Chemical Society Reviews, 2018 - pubs.rsc.org
Glycoconjugate vaccines obtained by chemical linkage of a carbohydrate antigen to a
protein are part of routine vaccinations in many countries. Licensed antimicrobial glycan …
protein are part of routine vaccinations in many countries. Licensed antimicrobial glycan …
Synthetic and immunological studies of Salmonella Enteritidis O-antigen tetrasaccharides as potential anti-Salmonella vaccines
CX Huo, D Dhara, SM Baliban, ST Nick, Z Tan… - Chemical …, 2019 - pubs.rsc.org
The first synthetic carbohydrate based potential anti-Salmonella Enteritidis vaccine has
been developed by conjugating a synthetic tetrasaccharide antigen with bacteriophage Qβ …
been developed by conjugating a synthetic tetrasaccharide antigen with bacteriophage Qβ …
Syntheses of Salmonella Paratyphi A Associated Oligosaccharide Antigens and Development towards Anti‐Paratyphoid Fever Vaccines
D Dhara, SM Baliban, CX Huo… - … A European Journal, 2020 - Wiley Online Library
With the emergence of multidrug resistant Salmonella strains, the development of anti‐
Salmonella vaccines is an important task. Currently there are no approved vaccines against …
Salmonella vaccines is an important task. Currently there are no approved vaccines against …