Evidence is accumulating that the risk of osteoporosis in later life may be determined in part
by environmental influences on bone development during intrauterine and early postnatal …

Background: The positive relationship between fat mass, bone mass and leptin has been
shown in fetal mouse cartilage/bone. It has been shown that umbilical venous leptin predicts …

This study investigates the relationship between leptin and fetal bone metabolism by
measuring fetal blood levels of leptin, carboxy-terminal pro-peptide of type I pro-collagen …

Recent discoveries of human genetic leptin deficiency have demonstrated its importance in
regulating weight gain in early childhood. To investigate whether normal variation in leptin …

Serum leptin concentrations and bone mass are concordant in several respects. Obesity is
associated with increased serum leptin concentrations and bone mineral, whereas …

Leptin is a 16-kD protein encoded by the ob/ob (obesity) gene. In rodents it plays a role in
obesity, diabetes, fertility, and neuroendocrine function. In humans serum concentrations of …

Objective: To determine the relationships among serum leptin, insulin-like growth factor-I,
and insulin levels in large for gestational age (LGA) infants. Methods: Serum samples were …

The insulin-like growth factor (IGF) system is the dominant endocrine regulator of fetal
growth, whereas insulin has a permissive role. Although a role for leptin in fetal growth has …

Fat mass is an important determinant of bone density, but the mechanism of this relationship
is uncertain. Leptin, as a circulating peptide of adipocyte origin, is a potential contributor to …

Leptin is secreted during pregnancy by the placenta and by the maternal and fetal adipose
tissues. The leptin levels mainly reflect the amount of fat stored and thus are indicative of the …