Embryonic stem (ES) cells give rise to all cell types of an organism. Since mutations at this
embryonic stage would affect all cells and be detrimental to the overall health of an …

Embryonic stem (ES) cells and germ cells have the potential to give rise to an entire
organism. A common requirement is that both must have very robust mechanisms to …

The maintenance of genomic integrity is crucial to embryonic stem cells (ESC) considering
the potential for propagating undesirable mutations to the resulting somatic and germ cell …

We recently demonstrated that human embryonic stem cells (hESCs) utilize homologous
recombination repair (HRR) as primary means of double-strand break (DSB) repair. We now …

Differences in ex vivo cell culture conditions can drastically affect stem cell physiology. We
sought to establish an assay for measuring the effects of chemical, environmental, and …

Accumulation of mutations in embryonic stem (ES) cells would be detrimental to an embryo
derived from these cells, and would adversely affect multiple organ systems and tissue …

Embryonic stem (ES) cells are rapidly proliferating, self-renewing cells that have the capacity
to differentiate into all three germ layers to form the embryo proper. Since these cells are …

DNA double-strand breaks (DSBs) may be caused by normal metabolic processes or
exogenous DNA damaging agents and can promote chromosomal rearrangements …

There are two types of chromosome instability, structural and numerical, and these are
important in cancer. Many structural abnormalities are likely to involve double-strand DNA …

Embryonic stem cells (ESCs) possess specific gene expression patterns that confer the
ability to proliferate indefinitely and enable pluripotency, which allows ESCs to differentiate …