Exploiting breakdown in nonhost effector–target interactions to boost host disease resistance

H McLellan, SE Harvey… - Proceedings of the …, 2022 - National Acad Sciences
Plants are resistant to most microbial species due to nonhost resistance (NHR), providing
broad-spectrum and durable immunity. However, the molecular components contributing to …

RxLR effectors: Master modulators, modifiers and manipulators

S Wang, H McLellan, PC Boevink… - Molecular Plant …, 2023 - Am Phytopath Society
Cytoplasmic effectors with an Arg-any amino acid-Arg-Leu (RxLR) motif are encoded by
hundreds of genes within the genomes of oomycete Phytophthora spp. and downy mildew …

Convergent targeting of a common host protein-network by pathogen effectors from three kingdoms of life

R Weßling, P Epple, S Altmann, Y He, L Yang… - Cell host & …, 2014 - cell.com
While conceptual principles governing plant immunity are becoming clear, its systems-level
organization and the evolutionary dynamic of the host-pathogen interface are still obscure …

Target the core: durable plant resistance against filamentous plant pathogens through effector recognition

JRL Depotter, G Doehlemann - Pest Management Science, 2020 - Wiley Online Library
Plant pathogens colonize their host through the secretion of effector proteins that modulate
plant metabolism and immune responses to their benefit. Plants evolve towards effector …

From effectors to effectomes: Are functional studies of individual effectors enough to decipher plant pathogen infectious strategies?

N Arroyo-Velez, M González-Fuente, N Peeters… - PLoS …, 2020 - journals.plos.org
Effector proteins of plant pathogens are key virulence determinants which can be secreted in
the apoplast or translocated inside plant cells where they subvert host immunity and …

Effector biology in focus: a primer for computational prediction and functional characterization

RJD Dalio, J Herlihy, TS Oliveira… - Molecular Plant …, 2018 - Am Phytopath Society
Plant–pathogen interactions are controlled by a multilayered immune system, which is
activated by pathogen recognition in the host. Pathogens secrete effector molecules to …

Host-interactor screens of Phytophthora infestans RXLR proteins reveal vesicle trafficking as a major effector-targeted process

B Petre, MP Contreras, TO Bozkurt, MH Schattat… - The Plant …, 2021 - academic.oup.com
Pathogens modulate plant cell structure and function by secreting effectors into host tissues.
Effectors typically function by associating with host molecules and modulating their activities …

Phytophthora parasitica Effector PpRxLR2 Suppresses Nicotiana benthamiana Immunity

RJD Dalio, HJ Maximo, TS Oliveira… - Molecular Plant …, 2018 - Am Phytopath Society
Phytophthora species secrete several classes of effector proteins during interaction with
their hosts. These proteins can have multiple functions including modulation of host …

A Phytophthora infestans RXLR effector targets plant PP1c isoforms that promote late blight disease

PC Boevink, X Wang, H McLellan, Q He… - Nature …, 2016 - nature.com
Plant pathogens deliver effectors to alter host processes. Knowledge of how effectors target
and manipulate host proteins is critical to understand crop disease. Here, we show that in …

Potato NPH3/RPT2-Like Protein StNRL1, Targeted by a Phytophthora infestans RXLR Effector, Is a Susceptibility Factor

L Yang, H McLellan, S Naqvi, Q He… - Plant …, 2016 - academic.oup.com
Plant pathogens deliver effectors to manipulate host processes. We know little about how
fungal and oomycete effectors target host proteins to promote susceptibility, yet such …