Genetic variance of a phenotypic trait can originate from direct genetic effects, or from
indirect effects, ie, through genetic effects on other traits, affecting the trait of interest. This …

A major goal in the study of complex traits is to decipher the causal interrelationships among
correlated phenotypes. Current methods mostly yield undirected networks that connect …

Large-effect loci—those statistically significant loci discovered by genome-wide association
studies or linkage mapping—associated with key traits segregate amidst a background of …

Biology is characterized by complex interactions between phenotypes, such as recursive
and simultaneous relationships between substrates and enzymes in biochemical systems …

The application of quantitative genetics in plant and animal breeding has largely focused on
additive models, which may also capture dominance and epistatic effects. Partitioning …

For most complex traits, results from genome-wide association studies show that the
proportion of the phenotypic variance attributable to the additive effects of individual SNPs …

Genetic effect estimates for loci detected in quantitative trait locus (QTL) mapping
experiments depend upon two factors. First, they are parameterizations of the genotypic …

Mediation analysis is used in genetic mapping studies to identify candidate gene mediators
of quantitative trait loci (QTL). We consider genetic mediation analysis of triplets—sets of …

Current efforts in systems genetics have focused on the development of statistical
approaches that aim to disentangle causal relationships among molecular phenotypes in …

Mapping quantitative trait loci (QTL) is often based on a functional or statistical model of
gene action involving two alleles per locus. Such model is adequate for mapping …