mTOR inhibition improves immune function in the elderly
JB Mannick, G Del Giudice, M Lattanzi… - Science translational …, 2014 - science.org
Inhibition of the mammalian target of rapamycin (mTOR) pathway extends life span in all
species studied to date, and in mice delays the onset of age-related diseases and …
species studied to date, and in mice delays the onset of age-related diseases and …
Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune‐deficient mice
The mammalian (mechanistic) target of rapamycin (mTOR) regulates critical immune
processes that remain incompletely defined. Interest in mTOR inhibitor drugs is heightened …
processes that remain incompletely defined. Interest in mTOR inhibitor drugs is heightened …
TORC1 inhibition enhances immune function and reduces infections in the elderly
Inhibition of the mechanistic target of rapamycin (mTOR) protein kinase extends life span
and ameliorates aging-related pathologies including declining immune function in model …
and ameliorates aging-related pathologies including declining immune function in model …
Targeting the biology of aging with mTOR inhibitors
JB Mannick, DW Lamming - Nature Aging, 2023 - nature.com
Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …
[HTML][HTML] mTOR signaling from cellular senescence to organismal aging
S Xu, Y Cai, Y Wei - Aging and disease, 2014 - ncbi.nlm.nih.gov
The TOR (target of rapamycin) pathway has been convincingly shown to promote aging in
various model organisms. In mice, inhibiting mTOR (mammalian TOR) by rapamycin …
various model organisms. In mice, inhibiting mTOR (mammalian TOR) by rapamycin …
Sex‐and tissue‐specific changes in mTOR signaling with age in C57 BL/6J mice
EL Baar, KA Carbajal, IM Ong, DW Lamming - Aging cell, 2016 - Wiley Online Library
Inhibition of the mTOR (mechanistic Target Of Rapamycin) signaling pathway robustly
extends the lifespan of model organisms including mice. The precise molecular mechanisms …
extends the lifespan of model organisms including mice. The precise molecular mechanisms …
A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive …
Inhibition of the mechanistic target of rapamycin (mTOR) pathway by rapamycin (RAPA), an
FDA-approved immunosuppressive drug used as a clinical therapy to prevent solid organ …
FDA-approved immunosuppressive drug used as a clinical therapy to prevent solid organ …
Intermittent administration of rapamycin extends the life span of female C57BL/6J mice
SI Arriola Apelo, CP Pumper, EL Baar… - … Series A: Biomedical …, 2016 - academic.oup.com
Inhibition of the mTOR (mechanistic target of rapamycin) signaling pathway by the FDA-
approved drug rapamycin promotes life span in numerous model organisms and delays age …
approved drug rapamycin promotes life span in numerous model organisms and delays age …
Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials
JB Mannick, G Teo, P Bernardo, D Quinn… - The Lancet Healthy …, 2021 - thelancet.com
Background The COVID-19 pandemic highlights the need for therapies that improve
immune function in older adults, including interferon (IFN)-induced antiviral immunity that …
immune function in older adults, including interferon (IFN)-induced antiviral immunity that …
Lifespan‐extending caloric restriction or m TOR inhibition impair adaptive immunity of old mice by distinct mechanisms
EL Goldberg, MJ Romero‐Aleshire, KR Renkema… - Aging cell, 2015 - Wiley Online Library
Aging of the world population and a concomitant increase in age‐related diseases and
disabilities mandates the search for strategies to increase healthspan, the length of time an …
disabilities mandates the search for strategies to increase healthspan, the length of time an …