Roles of G protein-coupled receptors (GPCRs) in gastrointestinal cancers: focus on sphingosine 1-shosphate receptors, angiotensin ii receptors, and estrogen-related …

Z Zeng, C Ma, K Chen, M Jiang, R Vasu, R Liu, Y Zhao… - Cells, 2021 - mdpi.com
It is well established that gastrointestinal (GI) cancers are common and devastating diseases
around the world. Despite the significant progress that has been made in the treatment of GI …

An Update of G-Protein-Coupled Receptor Signaling and Its Deregulation in Gastric Carcinogenesis

H Yan, JL Zhang, KT Leung, KW Lo, J Yu, KF To… - Cancers, 2023 - mdpi.com
Simple Summary Gastric cancer (GC) ranks as one of the most life-threatening malignancies
worldwide, and over one billion new cases and 783,000 deaths were reported last year. The …

G protein-coupled receptors in cancer

R Bar-Shavit, M Maoz, A Kancharla, JK Nag… - International journal of …, 2016 - mdpi.com
Despite the fact that G protein-coupled receptors (GPCRs) are the largest signal-conveying
receptor family and mediate many physiological processes, their role in tumor biology is …

G protein-coupled receptors as promising cancer targets

Y Liu, S An, R Ward, Y Yang, XX Guo, W Li, TR Xu - Cancer letters, 2016 - Elsevier
G protein-coupled receptors (GPCRs) regulate an array of fundamental biological
processes, such as growth, metabolism and homeostasis. Specifically, GPCRs are involved …

G-protein-coupled receptors and cancer

RT Dorsam, JS Gutkind - Nature reviews cancer, 2007 - nature.com
G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved
in signal transmission, have recently emerged as crucial players in tumour growth and …

GPCRs and cancer

R Lappano, M Maggiolini - Acta pharmacologica sinica, 2012 - nature.com
G-protein-coupled receptors (GPCRs), which represent the largest gene family in the human
genome, play a crucial role in multiple physiological functions as well as in tumor growth …

G protein-coupled receptors: novel targets for drug discovery in cancer

R Lappano, M Maggiolini - Nature reviews Drug discovery, 2011 - nature.com
G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signalling
proteins that have a pivotal role in many physiological functions and in multiple diseases …

GPCRs: Emerging anti-cancer drug targets

AN Gutierrez, PH McDonald - Cellular signalling, 2018 - Elsevier
G protein-coupled receptors (GPCRs) constitute the largest and most diverse protein family
in the human genome with over 800 members identified to date. They play critical roles in …

Harnessing the genome for characterization of G‐protein coupled receptors in cancer pathogenesis

ME Feigin - The FEBS journal, 2013 - Wiley Online Library
G‐protein coupled receptors (GPCRs) mediate numerous physiological processes and
represent the targets for a vast array of therapeutics for diseases ranging from depression to …

An insight into GPCR and G-proteins as cancer drivers

PK Chaudhary, S Kim - Cells, 2021 - mdpi.com
G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling
receptors known to play a crucial role in various physiological functions, including tumor …