Roles of G protein-coupled receptors (GPCRs) in gastrointestinal cancers: focus on sphingosine 1-shosphate receptors, angiotensin ii receptors, and estrogen-related …
Z Zeng, C Ma, K Chen, M Jiang, R Vasu, R Liu, Y Zhao… - Cells, 2021 - mdpi.com
It is well established that gastrointestinal (GI) cancers are common and devastating diseases
around the world. Despite the significant progress that has been made in the treatment of GI …
around the world. Despite the significant progress that has been made in the treatment of GI …
An Update of G-Protein-Coupled Receptor Signaling and Its Deregulation in Gastric Carcinogenesis
Simple Summary Gastric cancer (GC) ranks as one of the most life-threatening malignancies
worldwide, and over one billion new cases and 783,000 deaths were reported last year. The …
worldwide, and over one billion new cases and 783,000 deaths were reported last year. The …
G protein-coupled receptors in cancer
Despite the fact that G protein-coupled receptors (GPCRs) are the largest signal-conveying
receptor family and mediate many physiological processes, their role in tumor biology is …
receptor family and mediate many physiological processes, their role in tumor biology is …
G protein-coupled receptors as promising cancer targets
Y Liu, S An, R Ward, Y Yang, XX Guo, W Li, TR Xu - Cancer letters, 2016 - Elsevier
G protein-coupled receptors (GPCRs) regulate an array of fundamental biological
processes, such as growth, metabolism and homeostasis. Specifically, GPCRs are involved …
processes, such as growth, metabolism and homeostasis. Specifically, GPCRs are involved …
G-protein-coupled receptors and cancer
RT Dorsam, JS Gutkind - Nature reviews cancer, 2007 - nature.com
G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved
in signal transmission, have recently emerged as crucial players in tumour growth and …
in signal transmission, have recently emerged as crucial players in tumour growth and …
GPCRs and cancer
R Lappano, M Maggiolini - Acta pharmacologica sinica, 2012 - nature.com
G-protein-coupled receptors (GPCRs), which represent the largest gene family in the human
genome, play a crucial role in multiple physiological functions as well as in tumor growth …
genome, play a crucial role in multiple physiological functions as well as in tumor growth …
G protein-coupled receptors: novel targets for drug discovery in cancer
R Lappano, M Maggiolini - Nature reviews Drug discovery, 2011 - nature.com
G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signalling
proteins that have a pivotal role in many physiological functions and in multiple diseases …
proteins that have a pivotal role in many physiological functions and in multiple diseases …
GPCRs: Emerging anti-cancer drug targets
AN Gutierrez, PH McDonald - Cellular signalling, 2018 - Elsevier
G protein-coupled receptors (GPCRs) constitute the largest and most diverse protein family
in the human genome with over 800 members identified to date. They play critical roles in …
in the human genome with over 800 members identified to date. They play critical roles in …
Harnessing the genome for characterization of G‐protein coupled receptors in cancer pathogenesis
ME Feigin - The FEBS journal, 2013 - Wiley Online Library
G‐protein coupled receptors (GPCRs) mediate numerous physiological processes and
represent the targets for a vast array of therapeutics for diseases ranging from depression to …
represent the targets for a vast array of therapeutics for diseases ranging from depression to …
An insight into GPCR and G-proteins as cancer drivers
PK Chaudhary, S Kim - Cells, 2021 - mdpi.com
G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling
receptors known to play a crucial role in various physiological functions, including tumor …
receptors known to play a crucial role in various physiological functions, including tumor …