Leukocyte infiltration and persistence within peripheral nerves have been implicated in
chronic nociception pathogenesis in murine peripheral neuropathy models. Endoneurial …

IL-1β and TNF are potential targets in the management of neuropathic pain after injury.
However, the importance of the IL-1 and TNF systems for peripheral nerve regeneration and …

The present study was undertaken to determine whether leukocytes are recruited into the
spinal cord following a peripheral L5 spinal nerve transection that results in mechanical …

In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

Cytotoxicity and consequent cell death pathways are a critical component of the immune
response to infection, disease or injury. While numerous examples of inflammation causing …

The role of innate and adaptive inflammation as a primary driver or modifier of neuropathy in
premorbidly normal nerves, and as a critical player in amplifying neuropathies of other …

Introduction In patients with peripheral neuropathies (PNP), neuropathic pain is present in
50% of the cases, independent of the etiology. The pathophysiology of pain is poorly …

Neuropathic pain represents a major problem in clinical medicine because it causes
debilitating suffering and is largely resistant to currently available analgesics. A …

Numerous preclinical studies support the role of spinal neuroimmune activation in the
pathogenesis of chronic pain, and targeting glia (eg, microglia/astrocyte)-or macrophage …

Partial sciatic nerve injury is a common model of neuropathic pain in rodents, and produces
both mechanical and thermal pain hypersensitivity. Several types of immune cells have …