Amyotrophic lateral sclerosis (ALS) is a rare disease involving selective and progressive
degeneration and disappearance of motor neurons. Oxidative stress is believed to …

The etiology of amyotrophic lateral sclerosis (ALS) is unknown. Oxidative stress may be one
of the major mechanisms involved. In vitro and in vivo data of edaravone suggest that it may …

Introduction: Amyotrophic lateral sclerosis (ALS) is a progressive, fatal, neurodegenerative
disease. Although the pathogenesis remains unresolved, oxidative stress is known to play a …

Introduction: Amyotrophic lateral sclerosis (ALS) is a progressive fatal disorder that affects all
skeletal muscles, leading to death, mostly within 2–4 years from onset. To date, the anti …

Amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig's disease, is a fatal
motor neuron degenerative disorder leading to paralysis and eventual death. At present, we …

Objectives and methods: Compared to age-matched healthy controls (n= 55), patients with
amyotrophic lateral sclerosis (ALS)(n= 26) showed increased oxidative stress as indicated …

Abstract Background In a Phase 3 study, amyotrophic lateral sclerosis (ALS) patients
experienced significantly less physical functional decline with 24‐week edaravone vs …

Our objective was to confirm the efficacy and safety of edaravone in amyotrophic lateral
sclerosis (ALS) patients. We conducted a 36-week confirmatory study, consisting of 12-week …

抄録 Edaravone is a low-molecular-weight antioxidant drug targeting peroxyl radicals
among many types of reactive oxygen species. Because of its amphiphilicity, it scavenges …

Free radical accumulation and oxidative stress have been proposed as contributing to the
progression of amyotrophic lateral sclerosis (motor neuron disease). A range of antioxidant …